Detail of "1590-08-5"

Reference

100 MHz NMR spectra and conformational analysis of some methyl and trimethyl derivatives of 1-tetralone

100 MHz NMR spectra and conformational analysis of some methyl and trimethyl derivatives of 1-tetralone. Bergesen, Knut; Cook, Michael J.; Hock, Teh Kim (Kjemisk Inst., Univ. Bergen, Bergen, Norway).Some commonly used reagents like 1590-08-5 and 19832-98-5 are used in this experiment. Org. Magn. Reson., 8(10), 513-17 (English) 1976. CODEN: ORMRBD. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) The 100 MHz NMR spectra of 2-methyl-(I), 4-methyl-(II), 4,5,8-(III), and 4,5,7-trimethyl-1-tetralone (IV) were analyzed as 8-spin systems using iterative computation. I and II exist in inverting half-chair conformations, the Me group in I favoring the equatorial site, whereas the Me group in II exists equally in the equatorial and axial sites. The 5-Me substituent in III and IV constrains the 4-Me group to the axial site; the rings adopt non-half-chair conformations. The NMR spectrum of 3-methyl-1-tetralone is discussed. .

An evaluation of four commercial HPLC chiral detectors: A comparison of three polarimeters and a circular dichroism detector

All Rights Reserved.Some chemicals with cas registry numbers like 1590-08-5 and 2749-07-7 are also used. An evaluation of four commercial HPLC chiral detectors: A comparison of three polarimeters and a circular dichroism detector. Kott, Laila; Holzheuer, W. Brian; Wong, Megan M.; Webster, Gregory K. (Analytical Research & Development, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA). Journal of Pharmaceutical and Biomedical Analysis, 43(1), 57-65 (English) 2007 Elsevier B.V. CODEN: JPBADA. ISSN: 0731-7085. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) With increasing frequency, new drug candidates being introduced into pharmaceutical drug pipelines are chiral. Often only one enantiomer exhibits the desired biol. activity and the other enantiomer may exhibit undesired side effects, thereby making chiral purity an important parameter. The introduction of chiral anal. adds addnl. complications in drug development. The pharmaceutical industry is constantly striving to streamline processes and improve efficiencies in an effort to move mols. to market quickly. In order to simplify the process of chiral method development, chiral screening can be set up, however a successful chiral screen depends on optimizing two factors: the column and the detector. The following work investigated the second factor and evaluated two types of com. available chiral detectors for their possible use in chiral method development and screening: polarimeters and CD detectors. Linearity, precision, and the limit of detection (LD) of six compds. (trans-stilbene oxide, Et chrysanthemate, propranolol, 1-methyl-2-tetralone, naproxen, Me methionine) on four com. detectors (three polarimeters and one CD detector) were detd. exptl. and the limit of quantitation calcd. from the exptl. LD. Trans-stilbene oxide worked well across all the detectors, showing good linearity, precision and low detection limits. However, the other five compds. proved to be more discriminating and showed that the CD detector performed better as a detector for chiral screens, over the polarimeters. .