Detail of "1594-57-6"

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CAS Number:
1594-57-6
Name:
4-Pyridinecarboximidamide,N-hydroxy-
Molecular Structure:
Formula:
C₆H₇N₃O
Molecular Weight:
137.14
Synonyms:
NSC 43969;N'-Hydroxyisonicotinimidamide;N'-Hydroxypyridine-4-carboximidamide;Pyridine-4-amidoxime;Isonicotinamide oxime;N-Hydroxy-4-pyridinecarboximidamide;N-Hydroxyisonicotinamidine;Isonicotinamidoxime(6CI,7CI,8CI);4-Pyridinecarboxamidoxime;4-Pyridinecarboxamide oxime;
Density:
1.32 g/cm³
Melting Point:
128-133 °C(lit.)
Boiling Point:
350.038 °C at 760 mmHg
Flash Point:
165.497 °C
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-36 Details

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Supplier:ChemOrganic Limited [ China (Mainland)]

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CAS Number: 1594-57-6 Formula:C6H7N3O N-Hydroxy-isonicotinamidine or 4-Pyridylamidoxime FW: 137.142 Purity: 97%

Supplier:YaLe chemical Co.ltd. [ China (Mainland)]

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Potential acetylcholinesterase reactivators: Potential acetylcholinesterase reactivators. Oxime and amidoxime derivatives. Serafin, Barbara; Majewski, Marek; Kleinrok, Zdzislaw; Jagiello-Wojtowicz, Ewa; Rajtar, Grayna; Sieklucka-Dziuba, Maria; Kolasa, Krystyna (Inst. Org. Chem. Technol., Tech. Univ. Warsaw, Warsaw, Pol.).Some commonly used reagents like 1594-57-6 and 62036-68-4 are used in this experiment. Arch. Immunol. Ther. Exp., 24(6), 901-10 (English) 1976. CODEN: AITEAT. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 1, 28 Of 12 oximes and amidoximes synthesized, only 1-methylbenzimidazole-2-aldoxime methiodide (I) [21749-67-7], pyridine-4-aldoxime dodecyl bromide (II) [62036-67-3], and pyridine-2-aldoxime dodecyl bromide (III) [62036-66-2] had antilethal effects in diiso-Pr fluorophosphonate (IV) [55-91-4]-poisoned mice when administered i.p. in 0.1 LD50 doses. These 3 compds. (10-6 M) also reactivated (100%) in vitro acetylcholinesterase [9000-81-1] in human erythrocyte hemolyzates poisoned with IV; however, administration of I, II, or III (0.2 LD50, i.p.) had no effect on the inhibited acetylcholinesterase activity in the brain or blood of rats pretreated with IV. Apparently, addn. of a dodecyl chain to pyridinealdoximes, and replacement of the pyridine ring with benzimidazole in aldoximes, distinctly increase lipophilicity of these compds. and intensify their protective action in animals poisoned with IV. .