Reference

Preparation of prolyl tripeptides as hepatitis C virus inhibitors

All Rights Reserved. Preparation of prolyl tripeptides as hepatitis C virus inhibitors.Several substances are used for example 919093-90-6 and 159622-10-3 which are their cas registry numbers. Hewawasam, Piyasena; Ding, Min; Sun, Li-Qiang; Scola, Paul Michael (USA ). U.S. Pat. Appl. Publ. US 2007010455 A1 11 Jan 2007,86pp. (English). (United States of America). CODEN: USXXCO. INCL: 514018000; 514300000; 514314000; 530331000. APPLICATION: US 2006-481536 6 Jul 2006. PRIORITY: US 2005-698172P 11 Jul 2005. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 1, 63 The disclosure relates to tripeptide compds., compns. and methods for the treatment of hepatitis C virus (HCV) infection. Prolyl tripeptides I [A is alkoxy, OH, or sulfonylamino; n is 1 or 2; R2 is H, (halo)alkyl, (halo)alkenyl, or (halo)cycloalkyl; W is H, (un)substituted alkyl or alkylcarbonyl; Y is acyl, carboxy or ester, (thio)carbamoyl, sulfonyl, etc.; B is H, alkyl, aryl, heteroaryl, acyl, etc.; R3 is H, alkyl, alkoxy, alkylamino, aryl, etc.], including enantiomers, diastereomers, and pharmaceutically-acceptable salts, are claimed. Thus, peptide II (a mixt. of diastereomers) was prepd. via N-acylation reactions in soln. and showed IC50 < 0.15 mM and EC50 0.15-15 mM in the NS3/4A protease inhibition assay. .