Detail of "1597-82-6"

CAS Number:
1597-82-6
Name:
Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6-fluoro-11,17-dihydroxy-16-methyl-, (6a,11b,16a)-
Molecular Structure:
Formula:
C24H31 F O6
Molecular Weight:
434.55
Synonyms:
Pregna-1,4-diene-3,20-dione,6a-fluoro-11b,17,21-trihydroxy-16a-methyl-, 21-acetate(6CI,7CI,8CI); 16a-Methyl-6a-fluoroprednisolone 21-acetate;21-Acetoxy-6a-fluoro-11b,17-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione;21-Acetyl-6a-fluoro-16a-methylprednisolone; 6a-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione21-acetate; 6a-Fluoro-16a-methylprednisolone 21-acetate;Alondra; Cortidene; Dilar; Dillar; Flumethone; Haldrate; Haldrone; Metilar;Monocortin; Paramethasone 21-acetate; Paramethasone acetate; Paramezone;Stemex; Syntecort
EINECS:
216-486-4
Density:
1.29 g/cm1.29 g/cm3
Boiling Point:
584.2 °C at 760 mmHg
Flash Point:
307.1 °C
Safety:
Poison by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of F⁻. Details

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Paramethasone acetate (PA): corticosteroid potency vs: Paramethasone acetate (PA): corticosteroid potency vs. hypothalamic pituitary-gonadal axis. Cortes-Gallegos, V.; Alonso, R.; Castaneda, G.; Sojo, I.; Carranco, A.; Cervantes, C.; Parra, A. (Div. Fisiol. Gonadal Endocrinol., IMSS, Mexico City 03020, Mex.). J. Steroid Biochem., 20(1), 353-6 (English) 1984. 521-18-6 and 9002-62-4 are cas registry numbers of chemicals which are used as reagents here. CODEN: JSTBBK. ISSN: 0022-4731. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Paramethasone acetate (PA) [1597-82-6] is known to suppress basal and midcycle LH [9002-67-9] surge and to block estrogen synthesis in the female, so its possible effect upon testicular physiol. was evaluated in healthy men. Circulating levels of FSH [9002-68-0], LH, prolactin (PRL) [9002-62-4], testosterone (T) [58-22-0], dihydrotestosterone (DHT) [521-18-6], androstenedione (A) [63-05-8], estradiol (E2) [50-28-2], and cortisol (C) [50-23-7] were detd. every 4 h throughout the day, before (control) and after PA (6 mg/d/7 d). PA suppressed neither the basal nor circadian rhythm of T and had no effect on LH, FSH, or PRL output. DHT, A, and E2 were reduced and the basal concns. and circadian variations of C were abolished. PA showed a dual control on the pituitary gonadal axis, causing a maximal suppression of adrenocortical activity and no interference in testosterone synthesis. .

Thin-layer chromatographic separation of corticosteroids from their respective 17-oxo-oxidation products: Thin-layer chromatographic separation of corticosteroids from their respective 17-oxo-oxidation products. Lanouette, Monique; Lodge, Bruce A. (Drug Res. Lab., Health Prot. Branch, Ottawa, Ont., Can.). J. Chromatogr., 129, 475-7 (English) 1976. CODEN: JOCRAM. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Eight corticosteroids were sepd. from their resp. 17-oxo oxidn.In this article, certain chemicals are used. Some of their cas registry numbers are 50-24-8 and 382-44-5 products by thin-layer chromatog. on silica gel plates using :50 and :50 CH2Cl2-dioxane-water as the solvent systems and UV light for detection. Fludrocortisone acetate [514-36-3], paramethasone acetate [1597-82-6], and triamcinolone [124-94-7], whose oxidn. products were not available, were also studied. E.g., prednisone [53-03-2], 1,4-androstadiene-3,11,17-trione [7738-93-4] (its oxidn. product), and prednisone 21-acetate [125-10-0] were sepd. in both solvent systems. In all cases oxidn. products could be detected at .gtoreq.0.4 .mu.g. .