Detail of "1600-44-8"

Reference

Inhibition of alcohol metabolism by tetramethylene sulfoxides

Inhibition of alcohol metabolism by tetramethylene sulfoxides. Plapp, Bryce V.; Chadha, Vijay K. (University of Iowa Research Foundation, USA). U.S. US 4482568 A 13 Nov 1984, 7 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-38; C07D333-00. NCL: 424275000. APPLICATION: US 83-542482 17 Oct 1983. DOCUMENT TYPE: Patent CA Section: 4 (Toxicology) Section cross-reference(s): 27 Tetramethylene sulfoxides which noncompetitively bind alc. dehydrogenase [9031-72-5] of the liver of warm-blooded animals and thereby prevent the metab.Several substances like 9031-72-5 may be metioned in this study. of alcs., esp. toxic alcs. such as MeOH [67-56-1], iso-PrOH [67-63-0], and ethylene glycol [107-21-1] were prepd. and tested. Thus, tetramethylene sulfoxide [1600-44-8], 3-methyltetramethylene sulfoxide (I) [93111-02-5], and 3-butyltetramethylene sulfoxide [93111-03-6] were synthesized and shown to be noncompetitive inhibitors of alc. dehydrogenases from the livers of several animals in vitro with EtOH [64-17-5] as substrate; in addn. in vivo EtOH metab. by rats was inhibited by 63, 72, and 76% by I, and 3-methyl-, 3-butyltetramethylene sulfoxides, resp., at 2-20 mmol/kg. DMSO was not an effective inhibitor of alc. dehydrogenase in vitro. .

The first combinatorially prepared and evaluated inorganic catalysts

The first combinatorially prepared and evaluated inorganic catalysts. Polyoxometalates for the aerobic oxidation of the mustard analog tetrahydrothiophene (THT).Several substances are used for example 58071-93-5 and 1600-44-8 which are their cas registry numbers. Hill, Craig L.; Damico Gall, Robin (Department of Chemistry, Emory University, Atlanta, GA 30322, USA). Journal of Molecular Catalysis A: Chemical, 114(1-3), 103-111 (English) 1996 Elsevier. CODEN: JMCCF2. ISSN: 1381-1169. DOCUMENT TYPE: Journal CA Section: 67 (Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms) Section cross-reference(s): 27 The combinatorial synthesis and evaluation of inorg. catalysts is described. The catalysts are an array of early-transition-metal-oxygen-anion clusters (polyoxometalates) and the reaction is the aerobic oxidn. of a mustard thioether analog, tetrahydrothiophene (THT). Selective oxidn. of THT to the desired sulfoxide, THTO, was achieved in high selectivity (>99%) and under relatively mild conditions (95°C, 1.52 atm). Solns. with a molar ratio of 1:2 (phosphorus:vanadium) had the highest catalytic activity. 51V NMR and IR were used not only to identify the self assembling polyoxometalates in several representative precursor combinations but also to assess the stability of one representative polyoxometalate catalyst, 1P:2V:10W, under catalytic conditions (no decompn. after 50 turnovers). Gas chromatog. was sufficient to rapidly quantify the product (THTO) yields and selectivities of representative reactions. Combinatorial methodol. should be applicable to and provide the same advantages for discovery and optimization of catalysts as it has for pharmaceuticals. .