Reference

Synthesis of novel azapyridocyanines

Synthesis of novel azapyridocyanines. Munavalli, Shekhar; Hsu, Fu Lian; Poziomek, Edward J. (Dev. Eng. Cent. Res. Dir., U. S.In this article, certain chemicals are used. Some of their cas registry numbers are 1603-40-3 and 695-34-1 Army Chem. Res., Aberdeen Proving Ground, MD 21010-5423, USA). Heterocycles, 24(7), 1893-8 (English) 1986. CODEN: HTCYAM. ISSN: 0385-5414. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) A facile synthesis of azapyridocyanines e.g. I from substituted 2-aminopyridines and dihalomethane is described. The influence of the substituents on the course of the reaction and the scope of the synthesis have been further explored. .

Synthesis of pyridopyrimidone derivatives and their activity against P

Synthesis of pyridopyrimidone derivatives and their activity against P. Falciparum in vitro. Dominguez, Jose; Charris, Jaime; Iarrusso, Lucido; Lopez, Simon; Lobo, Gricela; Riggione, Flavia (Laboratorio de Sintesis Organica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas 1051, Venez.). Farmaco, 51(12), 781-784 (English) 1996 Societa Chimica Italiana. CODEN: FRMCE8. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 10 Pyridopyrimidone derivs. I (R = H, 9-Me, 8-Me, 7-Me) and II (R = H, 10-Me, 9-Me, 8-Me) were synthesized as potential antimalarial agents on the basis of the pharmacol. properties of existing quinolone analogs such as ciprofloxacin IC50 39.8 mM. Meanwhile among these new compds., only the 3-amino-7-methyl-1(H)pyrazolo[3,4-b]-pyrido[1,2:1'2']pyrimido-4-one (R = 9-Me), produces significant antimalarial activity IC50 0.42 mM against P. 1603-40-3 and 695-34-1 which are cas registry numbers of chemicals are mentioned. falciparum in vitro. The remaining compds. were effective as antimalarial agents leading from IC50 1.0 mM to IC50 4.47 mM. .