Reference

Substituted pyrazinecarboxamides: synthesis and biological evaluation

All Rights Reserved.Some chemicals with cas registry numbers like 1603-91-4 and 10272-07-8 are also used. Substituted pyrazinecarboxamides: synthesis and biological evaluation. Dolezal, Martin; Palek, Lukas; Vinsova, Jarmila; Buchta, Vladimir; Jampilek, Josef; Kralova, Katarina (Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove 500 05, Czech Rep.). Molecules, 11(4), 242-256 (English) 2006 Molecular Diversity Preservation International. URL: http://www.mdpi.org/molecules/papers/11040242.pdf. CODEN: MOLEFW. ISSN: 1420-3049. DOCUMENT TYPE: Journal; (online computer file) CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 11 Condensation of the acid chlorides of some substituted pyrazine-2-carboxylic acids (pyrazine-2-carboxylic acid, 6-chloropyrazine-2-carboxylic acid, 5-tert-butylpyrazine-2-carboxylic acid or 5-tert-butyl-6-chloropyrazine-2-carboxylic acid) with various ring-substituted aminothiazoles or anilines yielded a series of amides. The syntheses, anal. and spectroscopic data of thirty newly prepd. compds. are presented. Structure-activity relationships between the chem. structures and the antimycobacterial, antifungal and photosynthesis-inhibiting activity of the evaluated compds. are discussed. 3,5-Bromo-4-hydroxyphenyl derivs. of substituted pyrazinecarboxylic acid have shown the highest activity against Mycobacterium tuberculosis H37Rv (54-72% inhibition). The highest antifungal effect against Trichophyton mentagrophytes, the most susceptible fungal strain tested, was found for 5-tert-butyl-6-chloro-N-(4-methyl-1,3-thiazol-2-yl)pyrazine-2-carboxamid e (I, MIC = 31.25 mmol×mL-1). The most active inhibitors of oxygen evolution rate in spinach chloroplasts were 5-tert-butyl-6-chloro-N-(5-bromo-2-hydroxyphenyl)pyrazine-2-carboxami de (II, IC50 = 41.9 mmol×L-1) and 5-tert-butyl-6-chloro-N-(1,3-thiazol-2-yl)pyrazine-2-carboxamide (IC50 = 49.5 mmol×L-1). .

Reaction of 1,3-dibromo-and 1,3-dichloroacetone with 2-aminoazaheterocycles

Reaction of 1,3-dibromo-and 1,3-dichloroacetone with 2-aminoazaheterocycles.Several substances are used for example 1603-91-4 which is its cas registry number. Kovalenko, N. V.; Kutrov, G. P.; Filipchuk, Yu. V.; Kornilov, M. Yu. ( Taras Shevchenko Kiev State University, Kiev 01033, Ukraine). Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii), 38(5), 590-597 (English) 2002 Kluwer Academic/Consultants Bureau. CODEN: CHCCAL. ISSN: 0009-3122. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) The reactions of 1,3-dibromoacetone with 2-aminoazines and 2-aminoazoles has been carried out for the first time and the pure intermediate quaternary salts have been isolated. They undergo cyclization to the corresponding imidazoazines and imidazoazoles contg. a bromomethyl group. Similar condensations were carried out with 1,3-dichloroacetone. .