Detail of "1607-01-8"

Reference

Blood levels of the metabolites of glyceryl trinitrate and pentaerythritol tetranitrate after administration of a two-step preparation

Blood levels of the metabolites of glyceryl trinitrate and pentaerythritol tetranitrate after administration of a two-step preparation. Neurath, G. B.; Duenger, M. (Inst. Biopharm. Mikroanal., Hamburg, Ger.). Arzneim.-Forsch., 27(2), 416-19 (English) 1977. CODEN: ARZNAD. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Glyceryl trinitrate [55-63-0] and pentaerythritol tetranitrate [78-11-5] administered orally to humans were rapidly metabolized, and the peak blood concn. of glyceryl trinitrate metabolites, 1,2-glyceryl dinitrate [621-65-8] and 1,3-glyceryl dinitrate [623-87-0], appeared at 15 and 180 min. postadministration. The max. 78-11-5 and 621-65-8 are cas registry numbers of chemicals which are used as reagents here. level of 1-glyceryl mononitrate [624-43-1] and 2-glyceryl mononitrate [620-12-2] appeared at 120 min. Similar kinetics were obsd. with pentaerythritol dinitrate [1607-01-8] and mononitrate [1607-00-7]. A large part of the nitrate metabolites was excreted in urine as conjugates. The total excretion during the 1st 24 h accounted for 22% of the administered dose in the case of glyceryl trinitrate. In total, 19% of the dose of pentaerythritol trinitrate was found as nitrate metabolite in urine within 24 h. A method using gas-chromatog. is described for the detn. of glyceryl trinitrate and pentaerythritol tetranitrate in blood and urine. .

Decomposition products of PETN in postexplosion analysis

Decomposition products of PETN in postexplosion analysis.Some chemicals with cas registry numbers like 1607-17-6 and 78-11-5 are also used. Basch, Avraham; Margalit, Yair; Abramovich-Bar, Sara; Bamberger, Yair; Daphna, Dalia; Tamiri, Tsippy; Zitrin, Shmuel (Div. Crim. Identific., Isr. Natl. Police, Jerusalem, Israel). J. Energ. Mater., 4(1-4), 77-91 (English) 1986. CODEN: JOEMDK. ISSN: 0737-0652. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) TLC of postexplosion debris showed in some cases PETN [78-11-5] was accompanied by other compds. which reacted with Griess reagent. The possibility that these compds. could be lower nitrate esters of pentaerythritol (tri-, di- and mononitrate) was examd. Lower nitrate esters were obtained by hydrolysis of PETN and their structures were detd., following sepn., by mass spectrometry and NMR. Chromatog. data of these esters matched data of the compds. which accompanied PETN in certain postexplosion cases. The dinitrate [1607-01-8] and trinitrate ester [1607-17-6] of pentaerythritol were isolated from postexplosion exts. and their structures confirmed by mass spectrometry and NMR. .