CAS No.1617-90-9,Vincamine Suppliers

Products Categories

Pharmaceutical (160)
Others (30)
Organic Chemicals (25)
Plant Extract (22)
Reagent (6)
(1)
Food Additives (1)
Materials (1)

Basic Information

Molecular Structure:
CAS No.:	1617-90-9
Name:	Vincamine
Article Data:	43

Formula:	C₂₁H₂₆N₂O₃
Molecular Weight:	354.449
Synonyms:	Vincapan;Pervincamine;Decincan;Eburnamenine-14-carboxylic acid,14,15-dihydro-14-hydroxy-,methyl ester,(3R,14a,16R)-;Vincamidol;Perval;Methyl vincaminate;Monorin;Eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-, methyl ester, (3alpha,14beta,16alpha)-;Minorin;Vinkametrin;Vinca-Ecobi;Anasclerol;Vincimax;Eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-, methyl ester, (3.alpha.,14.beta.,16.alpha.)-;Vinca-Minor;Equipur;Minorine;
EINECS:	216-576-3
Density:	1.36 g/cm³
Melting Point:	232 °C (dec.)(lit.)
Boiling Point:	508.9 °C at 760 mmHg
Flash Point:	261.6 °C
Appearance:	white to almost white fine crystalline powder
Hazard Symbols:	Xn
Risk Codes:	22
Safety:	36
PSA:	54.70000
LogP:	2.89040

Synthetic route

: 142892-63-5
(+)-15α-Chloro-vincamine

: 1617-90-9
vincamin

Conditions

Conditions	Yield
With hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal In methanol for 6h; Ambient temperature;	84.7%

: 6835-99-0
14-epivincamine

A: 1617-90-9
vincamin

B: 4880-92-6
apovincamine

Conditions

Conditions	Yield
at 250℃; for 0.25h;	A 7% B 83%
at 20℃; for 0.25h;	A 8% B 75%

: 3247-10-7
(-)-vincadifformine

: 1617-90-9
vincamin

Conditions

Conditions	Yield
Stage #1: (-)-vincadifformine With monoperoxymaleic acid In methanol at -5 - 0℃; for 6.16667h; Stage #2: With sodium dithionate at 40℃; for 3h; Reagent/catalyst;	78.3%

: 66113-74-4
hydroxy-16 dehydro-1 vincadifformine

A: 1617-90-9
vincamin

B: 4880-88-0
vinburnine

Conditions

Conditions	Yield
In toluene at 450℃; under 20 Torr;	A 5% B 70%

: 96861-85-7
O-methyl vincamine

A: 6835-99-0
14-epivincamine

B: 1617-90-9
vincamin

Conditions

Conditions	Yield
With hydrogenchloride In acetone for 72h; Ambient temperature; Yields of byproduct given;	A n/a B 66%

: 85588-92-7
(-)-methyl 1,2,3,4,6,7,12,12bα-octahydroindolo<2,3-a>quinolizine(1β-yl) pyruvate oxime

A: 6835-99-0
14-epivincamine

B: 1617-90-9
vincamin

Conditions

Conditions	Yield
With sodium disulfite; acetic acid In water at 90 - 92℃; for 6h; Yields of byproduct given;	A n/a B 60%
With sodium disulfite; acetic acid In water at 90 - 92℃; for 6h; Yield given. Title compound not separated from byproducts;	A n/a B 60%
With sodium disulfite; acetic acid In water at 92 - 95℃; for 5h;	A 20% B 40%

: 66113-74-4
hydroxy-16 dehydro-1 vincadifformine

A: 6835-99-0
14-epivincamine

B: 1617-90-9
vincamin

Conditions

Conditions	Yield
at 150℃; for 0.25h;	A 35% B 60%
at 150℃; for 0.25h; other condition;	A 35% B 60%
In acetic acid at 20℃; for 12h;	A 4 mg B 50 mg
In acetic acid for 12h; Ambient temperature;	A 4 mg B 50 mg

: 75-09-2
dichloromethane

: 94-81-5
MCPB

: 584-08-7
potassium carbonate

A methyl 3-benzyl-4,4-diethyl-6-hydroxy-2,3,3,a4,5,6-hexahydro-1H-indolo(3,2,1-de)(1,5)naphthyridine-6-carboxylate: methyl 3-benzyl-4,4-diethyl-6-hydroxy-2,3,3,a4,5,6-hexahydro-1H-indolo(3,2,1-de)(1,5)naphthyridine-6-carboxylate

B: 1617-90-9
vincamin

Conditions

Conditions	Yield
With hydrogenchloride; ammonia; sodium chloride In methanol	A n/a B 58%

...Expand

: 6835-99-0
14-epivincamine

A: 1617-90-9
vincamin

B: 4880-88-0
vinburnine

C: 4880-92-6
apovincamine

Conditions

Conditions	Yield
In toluene at 400℃; under 20 Torr;	A 9% B 47% C 10%

...Expand

: 3247-10-7
(-)-vincadifformine

A: 6835-99-0
14-epivincamine

B: 1617-90-9
vincamin

Conditions

Conditions	Yield
With sodium hydroxide; oxygen; sodium acetate; rose bengal; sodium thiosulfate; acetic acid 1.) methanol, irradation, 60 min, 2.) H2O, 70 deg C, 20 min; Yield given. Multistep reaction;	A n/a B 46%
With sodium hydroxide; oxygen; sodium acetate; rose bengal; sodium thiosulfate; acetic acid 1.) methanol, irradation, 60 min, 2.) H2O; Yield given. Multistep reaction. Yields of byproduct given;
With sulfuric acid; ozone In methanol at 60℃; Yield given. Yields of byproduct given;

Raw Materials

6835-99-0

190378-58-6

67-56-1

61-54-1

Downstream Products

Total:190 Page 1 of 5 1 2 3 4 5 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 1617-90-9

Chemistry

Molecular Structure of Vincamine (CAS NO.1617-90-9):

Molecular Formula:C₂₁H₂₆N₂O₃
Molecular Weight: 354.44
CAS Registry Number: 1617-90-9
H bond acceptors: 5
H bond donors: 1
Freely Rotating Bonds: 4
Polar Surface Area: 43.7 Å²
Index of Refraction: 1.681
Molar Refractivity: 98.28 cm³
Molar Volume: 259.6 cm³
Surface Tension: 54.2 dyne/cm
Density: 1.36 g/cm³
Flash Point: 261.6 °C
Enthalpy of Vaporization: 82.06 kJ/mol
Boiling Point: 508.9 °C at 760 mmHg
Vapour Pressure: 3.53E-11 mmHg at 25°C
Melting point: 232 ^oC (dec.)
EINECS: 216-576-3
Storage temp: 2-8°C
Merck: 9983
Product Categories: Alkaloids;Biochemistry; Indole Alkaloids; AlkaloidAsymmetric Synthesis; Biochemicals Found in Plants; Chiral Building Blocks; Complex Molecules; Nutrition Research

Toxicity Data With Reference

1.	ipr-rat LD50:253 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 32 (1982),601.
2.	orl-mus LD50:1 g/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 10 (1960),811.
3.	ipr-mus LD50:215 mg/kg	EJMCA5 European Journal of Medicinal Chemistry. Chimie Therapeutique. 16 (1981),191.
4.	ivn-mus LD50:47,740 µg/kg	AGSOA6 Agressologie. Revue Internationale de Physio-Biologie et de Pharmacologie Appliquees aux Effets de l’Agression. 19 (1978),211.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NO_x. Used as a vasodilator.
Hazard Codes: Harmful Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 36
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: YY8575000

Specification

Vincamine , with CAS number of 1617-90-9, can be called Eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-, methyl ester, (3alpha,14beta,16.) ; Oligo Proanthocyanidin ; Vincasaunier ; Vincadar ; 14,15-Dihydro-14-hydroxyeburnamenine-14-carboxylic acid methyl ester ; Eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-, methyl ester, (3.alpha.,14.beta.,16.alpha.)- . It is a white to almost white fine crystalline powder, Vincamine is often used as a nootropic agent to combat the effects of aging, or in conjunction with other nootropics (such as piracetam) for a variety of purposes. Vincamine (CAS NO.1617-90-9) is a peripheral vasodilator that increases blood flow to the brain. Vincamine is an indole alkaloid (specifically a tryptamine) found in the leaves of Vinca minor, comprising about 25-65% of the indole alkaloids found in Vinca minor by weight. Vincamine is also found in the species Catharanthus roseus. Vincamine can be synthesized from related alkaloids.