CAS No.16255-48-4,Octadecanoic acid,(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl ester Suppliers

CAS Number:
16255-48-4
Name:
Octadecanoic acid,(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl ester
Superlist Name:
Eusynthomycin
Formula:
C₂₉H₄₆Cl₂N₂O₆
Molecular Structure:
Synonyms:
Octadecanoicacid, (2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl ester(9CI);Octadecanoic acid,2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl ester,[R-(R*,R*)]-;Stearic acid, a-ester with 2,2-dichloro-N-[b-hydroxy-a-(hydroxymethyl)-p-nitrophenethyl]acetamide(6CI);Stearic acid, a-ester with D-threo-(-)-2,2-dichloro-N-[b-hydroxy-a-(hydroxymethyl)-p-nitrophenethyl]acetamide (8CI);Acetamide,2,2-dichloro-N-[b-hydroxy-a-(hydroxymethyl)-p-nitrophenethyl]-,a-stearate, D-threo-(-)- (8CI);Chloramphenicol stearate;Chloramphenicol stearic acid ester;Eusynthomycin;Levomycetin stearate;Madomicetina;Stearic acid, ester with chloramphenicol;[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] octadecanoate;[R-(R*,R*)]-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl stearate;
Molecular Weight:
589.5913
EINECS:
240-363-4
Density:
1.151 g/cm³
Boiling Point:
708.6 °C at 760 mmHg
Flash Point:
382.3 °C

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Dissolution and enzymic hydrolysis of chloramphenicol palmitic and stearic esters: Dissolution and enzymic hydrolysis of chloramphenicol palmitic and stearic esters. Cameroni, R.; Coppi, G.; Gamberini, G.; Forni, F. (Inst. Pharm. Chem., Univ. Modena, Modena, Italy). Farmaco, Ed. Prat., 31(12), 615-24 (English) 1976. CODEN: FRPPAO. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 7 The dissoln. rates of 250 mg chloramphenicol palmitate (I palmitate) [530-43-8] polymorphs A and B and I stearate [16255-48-4] polymorphs A and B in 250 ml phosphate buffer pH 8.0 contg. 0.05% Tween 80 were 0.375, 2.250, 0.250, and 0.475 mg h-1, resp. The pancreatin [8049-47-6] hydrolysis rates of the same 4 compds. 16255-48-4 and 8049-47-6 are cas registry numbers of chemicals which are used as reagents here. under similar exptl. conditions were 0.103, 1.427, 0.046, and 0.914 h-1. Enzymatic hydrolysis rate does not depend on a normal process of dissoln. and pancreatic enzymes may act at the solid liq. interface on the film of mols. of the ester which are going into soln., thus favoring an eased release of the mols. from the crystal according to the conformational differences of the mols. themselves. .

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