Detail of "163150-12-7"

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NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice

NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice.In this study，163150-12-7 is also used. Kojima, Hideto; Fujimiya, Mineko (Section of Diabetes Endocrinology & Metabolism, Department of Medicine and Molecular & Cellular Biology, Baylor College of Medicine, Huston, TX 77030, USA). Jikken Igaku, 21(13), 1760-1763 (Japanese) 2003 Yodosha. CODEN: JIIGEF. ISSN: 0288-5514. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) Section cross-reference(s): 3 A review on the title study, discussing selection of candidate genes (e.g. Ipf1 (insulin promoter factor 1)), and in vitro model cells (IEC-6); selection of targe tissues and gene transfer; selection of differentiation factors (e.g. NeuroD-betacellulin) for Langerhans islets; and liver expression of Langerhans islets. .

Betacellulin promotes growth of the gastrointestinal organs and effects a diuresis in normal rats

Betacellulin promotes growth of the gastrointestinal organs and effects a diuresis in normal rats. Howarth, Gordon S.; Bastian, Susan E. P.; Dunbar, Andrew J.; Goddard, Chris (Cooperative Research Centre for Tissue Growth and Repair, University of Adelaide, Adelaide, Australia). Growth Factors, 21(2), 79-86 (English) 2003 Taylor & Francis Ltd. CODEN: GRFAEC. ISSN: 0897-7194. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) We investigated its physiol. effects in rats implanted with pumps to deliver vehicle or recombinant rat betacellulin [46 mg/day] for 7 days.In this article, certain chemicals are used. Some of their cas registry numbers are 50-99-7 and 163150-12-7 At kill, blood and gastrointestinal tissues were collected for detns. of betacellulin levels, proliferation (bromodeoxyuridine-BrdU incorporation), and growth. Plasma betacellulin levels were increased 8-fold compared to vehicle, while serum insulin, body wt., and food intake were decreased by 32, 15, and 9%, resp. Water intake, urine and fecal output and small intestinal wt. were resp. increased by 36, 78, 47, and 24%. Ileal and proximal colonic crypt depths were increased by 25 and 51% although the BrdU labeling index was unaffected. Betacellulin stimulated gastrointestinal growth, the increased responsiveness of the terminal ileum and colon suggesting therapeutic potential in disease conditions in which ileal or colonic re-growth is desirable. Betacellulin further stimulated a diuresis suggesting an addnl. role in fluid homeostasis. .