CAS No.16338-48-0,(S)-(-)-2-Amino-4-pentenoic acid Suppliers,MSDS download

Detail of "16338-48-0"

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CAS Number:

16338-48-0

Name:

(S)-(-)-2-Amino-4-pentenoic acid

Molecular Structure:

Formula:

C₅H₉NO₂

Molecular Weight:

115.13

Synonyms:

(2S)-2-aminopent-4-enoic acid;4-Pentenoic acid, 2-amino-, (S)-;(-)-Allylglycine;L-Allylglycine;(S)-2-Amino-4-pentenoic acid;L-alpha-Allyl-Gly;

Density:

1.098 g/cm³

Melting Point:

253-255 °C

Boiling Point:

231 °C at 760 mmHg

Flash Point:

93.5 °C

Solubility:

soluble in water

Appearance:

White to off-white crystalline powder

Hazard Symbols:

Risk Codes:

36/37/38

Safety:

26-36-37/39 Details

Reference

Strychnine and L-allylglycine but not bicuculline and picrotoxin induce transsynaptic degeneration following transection of the inferior alveolar nerve in adult rats: Strychnine and L-allylglycine but not bicuculline and picrotoxin induce transsynaptic degeneration following transection of the inferior alveolar nerve in adult rats. Sugimoto, Tomosada; Takemura, Motohide; Okubo, Johji; Sakai, Akira (Fac. Dent., Osaka Univ., Suita 565, Japan). Brain Res., 341(2), 393-8 (English) 1985. CODEN: BRREAP. ISSN: 0006-8993. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The effects of strychnine (I) [57-24-9] bicuculline [485-49-4], picrotoxin [124-87-8], and L-allylglycine [16338-48-0] on the transsynaptic destruction of medullary dorsal horn neurons were examd. following transection of the inferior alveolar nerve in adult rats. Strychnine and L-allylglycine enhanced the transsynaptic effect of nerve transection and caused degeneration of many dorsal horn neurons, whereas bicuculline and picrotoxin did not. The removal of glycinergic and GABAerigic postsynaptic inhibition appears to enhance the transsynaptic destructive activity which follows the peripheral nerve transection.

D- and L-stereoisomers of allylglycine: convulsive action and inhibition of brain L-glutamate decarboxylase: D- and L-stereoisomers of allylglycine: convulsive action and inhibition of brain L-glutamate decarboxylase. Orlowski, Marian; Reingold, Diane F.; Stanley, M. E. (Mount Sinai Med. Sch., City Univ. New York, New York, N. Y., USA). J. Neurochem., 28(2), 349-53 (English) 1977. CODEN: JONRA9. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 7 L- [16338-48-0] and D-allylglycine [54594-06-8] both acted as convulsants in mice, with the L-isomer being more potent than the D-isomer, possibly owing to slower penetration of the blood-brain barrier by the D-isomer. Both isomers inhibited brain glutamate decarboxylase (EC 4.1.1.15) (I) [9024-58-2] to a similar extent in vitro, but the L-isomer was the stronger inhibitor in vivo. Allylglycine concns. that inhibited I in vivo were ineffective in vitro. Allylglycine oxidn. products of L- or D-amino acid oxidase action inhibited I in vitro. A common intermediate (possibly 2-keto-4-pentenoic acid) may be responsible for the in vivo I inhibition and the induction of convulsions.

Detail of "16338-48-0"

(S)-(-)-2-Amino-4-pentenoic acid

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CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

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CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

CAS No.16338-48-0 (S)-(-)-2-Amino-4-pentenoic acid

Reference