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Detail of "163619-04-3"

  • MSDS Download
  • CAS Number:
  • 163619-04-3
  • Name:

  • Fmoc-D-Trp(Boc)-OH

  • Molecular Structure:
  • Formula:
  • C31H30N2O6
  • Molecular Weight:
  • 526.58
  • Synonyms:
  • N-α-Fmoc-N-in-Boc-D-tryptophan;N-alpha-Fmoc-N(in)-Boc-D-tryptophan;N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-in-tert-butyl-oxycarbonyl-D-tryptophan;
  • Density:
  • 1.289 g/cm3
  • Safety:
  • 22-24/25 Details
  • particular:
  • particular
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CAS No.163619-04-3 Fmoc-D-Trp(Boc)-OHCompetitive Product

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Supplier:Shanghai Yeexin Biochemtechco.,LTD [ China (Mainland)]

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Fmoc-D-Trp(Boc)

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CAS No.163619-04-3 Fmoc-D-Trp(Boc)-OH

Assay:99%  Appearance:White Powder  Package:bagsStorage:dry

N(alpha)-fmoc-N(in)-boc-D-tryptophan

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CAS No.163619-04-3 Fmoc-D-Trp(Boc)-OH

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CAS No.163619-04-3 Fmoc-D-Trp(Boc)-OH

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CAS No.163619-04-3 Fmoc-D-Trp(Boc)-OH

Name:Fmoc-D-Trp(Boc)-OH CAS No.:163619-04-3 Molecular Formula:C31H30N2O6 Molecular Weight:526.59 Purity (HPLC):97.5% min. Appearance:Faintly beige powder with lumps Melting Point:89.5 oC (dec.) Specific Rotation (20/D):+19±2.5o (c=1, DMF) 300 MHz 1H:Consisten

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Shanghai KLH Company [ China (Mainland)]

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CAS No.163619-04-3 Fmoc-D-Trp(Boc)-OH

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FMOC-D-TRP(BOC)-OH

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FMOC-D-TRP(BOC)-OH

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Reference

Preparation of lipopeptide antibiotic derivatives
Preparation of lipopeptide antibiotic derivatives. Cameron, Dale R.; Boyd, Vincent A.; Leese, Richard A.; Curran, William V.; Francis, Noreen D.; Jarolmen, Howard; Borders, Donald B.Chemicals with cas numbers 823780-73-0 and 163619-04-3 also play role.; Sgarbi, Paulo W. M.; Wacowich-Sgarbi, Shirley A.; Nodwell, Matthew; Chen, Yuchen; Jia, Qi (Micrologix Biotech Inc., Can.). PCT Int. Appl. WO 2005000878 A2 6 Jan 2005, 252 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07K007-56. ICS: A61K038-12; A61P031-04. APPLICATION: WO 2004-US21039 28 Jun 2004. PRIORITY: US 2003-PV482985 26 Jun 2003; US 2003-PV488331 17 Jul 2003; US 2004-PV564912 23 Apr 2004. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 10, 63 The invention provides derivs. of lipopeptide antibiotics that display antimicrobial activity against microorganisms and includes methods for their synthesis and use in the treatment and prevention of microbial infections. Compds. of formula I [R1 is OH or NH2; L is at least one (un)substituted amino acid or a carbonyl-contg. moiety; R2 is acyl, carboxy acid or ester, carbamoyl, thio- or iminocarbamoyl; R3 is OH, alkoxy, CN, NO2, N3, amino, acyl, sulfonyl, sulfinyl or phosphoryl group, (un)substituted alkyl or aryl, etc.] or their pharmaceutically-acceptable salts are claimed. Thus, C15-amphomycin-9-Gly was prepd. treating amphomycin-9-Fmoc (Fmoc = fluorenylmethoxycarbonyl) with succinimidyl-activated pentadecanoic acid and N-tert-butoxycarbonylglycine. C15-amphomycin-9-Gly showed MIC = 2 mg/mL against Staphylococcus aureus. .
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