Detail of "16364-31-1"

CAS Number:
16364-31-1
Name:
L-Glutamic acid,L-leucyl-
Molecular Structure:
Formula:
C11H20 N2 O5
Molecular Weight:
260.29
Synonyms:
Glutamicacid, N-L-leucyl-, L- (8CI); Glutamic acid, N-leucyl- (6CI,7CI); L-Glutamicacid, N-L-leucyl-; 39: PN: WO03052099 PAGE: 84 claimed protein; 455: PN:WO2005081628 SEQID: 1564 claimed protein; 74: PN: US20070066537 PAGE: 17claimed protein; L-Leucyl-L-glutamic acid; N-Leucylglutamic acid

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Glutamate-containing dipeptides enhance specific binding at glutamate receptors and inhibit specific binding at kainate receptors in rat brain: Glutamate-containing dipeptides enhance specific binding at glutamate receptors and inhibit specific binding at kainate receptors in rat brain. Ferkany, J.; Zaczek, R.; Markl, A.; Coyle, J. T. (Sch. Med.Some commonly used reagents like 16364-31-1 and 3617-45-6 are used in this experiment., Johns Hopkins Univ., Baltimore, MD 21205, USA). Neurosci. Lett., 44(3), 281-6 (English) 1984. CODEN: NELED5. ISSN: 0304-3940. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) L-Phenylalanyl-L-glutamate (PG) [3617-45-6] augmented the specific binding of the excitatory amino acid receptor antagonist 3H-labeled 2-amino-7-phosphonoheptanoic acid (APH) [85797-13-3] to rat forebrain membranes by 5-fold at 100 mM with an EC50 of 4.9 mM. The increase in the specific binding of [3H]AHP induced by PG resulted exclusively from an increase in Bmax. In contrast, PG inhibited the specific binding of 3H-labeled kainic acid [487-79-6] to forebrain membranes with a Ki of 6.8 mM. Of several related peptides examd., active ones affected the 2 receptor sites in a reciprocal fashion. The results suggest an allosteric interaction between [3H]APH and kainate receptors modulated by glutamate-contg. peptides. .