Detail of "16484-77-8"

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Comparative studies on the embryotoxicity of 2-methyl-4-chlorophenoxyacetic acid, mecoprop and dichlorprop in NMRI mice

Comparative studies on the embryotoxicity of 2-methyl-4-chlorophenoxyacetic acid, mecoprop and dichlorprop in NMRI mice. Roll, R.; Matthiaschk, G. (Max von Pettenkofer-Inst. Bundesgesundheitsamtes, Berlin, Fed. Rep. Ger.). Arzneim.-Forsch., 33(10), 1479-83 (German) 1983. CODEN: ARZNAD. ISSN: 0004-4172. 120-36-5 and 94-74-6 which are cas registry numbers are also used here. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Of the herbicidal phenoxycarboxylic acids, 2-methyl-4-chlorophenoxyacetic acid (MCPA) [94-74-6], 2-(4-chloro-2-methylphenoxy)propionic acid (mecoprop)(MCPP) [93-65-2], and 2-(2,4-dichlorophenoxy)propionic acid (dichlorprop)(2,4-DP) [120-36-5] as well as dextrorotatory MCPP (MCPPD) [16484-77-8] and dextrorotatory 2,4-DP (2,4-DPD) [15165-67-0] were given orally to mice at days 6-15 of pregnancy. All 5 were embryotoxic and teratogenic. MCPA was embryotoxic at 3100 mg/kg and teratogenic at 3200 mg/kg. The remaining compds. (MCPP, MCPPD, 2,4-DP, 2,4-DPD) were embryotoxic at 3300 mg/kg and caused malformations of the skeleton at 3400 mg/kg. The embryocidal and teratogenic potencies of MCPPD and 2,4-DPD exceeded those of the corresponding racemates. Effects of MCPPD and 2,4-DPD on postimplantation losses, frequency of cleft palates, and wavy ribs appeared at doses 100-200 mg/kg below those of the racemates. Addnl., alterations of the skeleton were obsd. that did not occur following the administration of the racemic mixt. .