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CAS No.: | 16588-75-3 |
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Name: | 2-METHOXY-5-TRIFLUOROMETHYLPHENYL ISOCYANATE |
Article Data: | 17 |
Molecular Structure: | |
Formula: | C9H6 F3 N O2 |
Molecular Weight: | 217.147 |
Synonyms: | Isocyanicacid, a,a,a-trifluoro-6-methoxy-m-tolyl ester (8CI);2-Isocyanato-1-methoxy-4-trifluoromethylbenzene;2-Methoxy-5-(trifluoromethyl)phenyl isocyanate |
Density: | 1.272g/cm3 |
Boiling Point: | 100-103℃ (10 Torr) |
Flash Point: | 94.592°C |
PSA: | 38.66000 |
LogP: | 2.68130 |
2-Methoxy-5-trifluoromethyl-aniline
trichloromethyl chloroformate
2-methoxy-5-trifluoromethylphenyl isocyanate
Conditions | Yield |
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With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane at 0 - 20℃; for 1.5h; | 88% |
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane at 0 - 20℃; for 1.5h; | 88% |
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In dichloromethane at 0 - 20℃; for 1.5h; | 88% |
phosgene
2-Methoxy-5-trifluoromethyl-aniline
2-methoxy-5-trifluoromethylphenyl isocyanate
Conditions | Yield |
---|---|
With pyridine In diethyl ether; dichloromethane; toluene | |
With pyridine In dichloromethane; toluene at 0 - 20℃; for 3.5h; | |
With sodium hydrogencarbonate In dichloromethane; water at 0℃; for 0.5h; |
4-(4-acetylphenoxy)-5-aminopyridine
2-Methoxy-5-trifluoromethyl-aniline
2-methoxy-5-trifluoromethylphenyl isocyanate
2-Methoxy-5-trifluoromethyl-aniline
N,N,N',N'-tetramethyl-1,8-diaminonaphthalene
trichloromethyl chloroformate
2-methoxy-5-trifluoromethylphenyl isocyanate
Conditions | Yield |
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In dichloromethane |
bis(trichloromethyl) carbonate
2-Methoxy-5-trifluoromethyl-aniline
2-methoxy-5-trifluoromethylphenyl isocyanate
Conditions | Yield |
---|---|
With pyrographite In ethyl acetate for 2h; Reflux; |
5-(4-aminophenoxy)isoindoline-1,3-dione
2-methoxy-5-trifluoromethylphenyl isocyanate
Conditions | Yield |
---|---|
In dichloromethane at 0 - 20℃; for 12 - 22h; Product distribution / selectivity; | 96% |
2-methoxy-5-trifluoromethylphenyl isocyanate
2-bromo-6-fluoroaniline
3-(2-bromo-6-fluorophenyl)-1-[2-methoxy-5-(trifluoromethyl)phenyl]urea
Conditions | Yield |
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In acetonitrile at 35 - 88℃; for 38 - 45h; Product distribution / selectivity; | 87.5% |
2-Fluoroaniline
2-methoxy-5-trifluoromethylphenyl isocyanate
N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea
Conditions | Yield |
---|---|
In acetonitrile at 82℃; for 4h; | 86.4% |
In acetonitrile for 4h; Reflux; Large scale; | 85.9% |
In acetonitrile at 0℃; for 7.25h; Reflux; Large scale; | 85.9% |
In acetonitrile for 4h; Reflux; Large scale; | 85.9% |
In acetonitrile Reflux; |
N-(4-fluoro-3-methylphenyl)-piperazine
(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester
2-methoxy-5-trifluoromethylphenyl isocyanate
Conditions | Yield |
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79% |
(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester
2-methoxy-5-trifluoromethylphenyl isocyanate
Conditions | Yield |
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In dichloromethane at 20℃; | 62% |