Detail of "1663-45-2"

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In vivo antitumor activity and in vitro cytotoxic properties of bis[1,2-bis(diphenylphosphino)ethane]gold(I) chloride

In vivo antitumor activity and in vitro cytotoxic properties of bis[1,2-bis(diphenylphosphino)ethane]gold(I) chloride. Berners-Price, Susan J.; Mirabelli, Christopher K.; Johnson, Randall K.; Mattern, Michael R.; McCabe, Francis L.; Faucette, Leo F.; Sung, Chiu Mei; Mong, Shau Ming; Sadler, Peter J.; Crooke, Stanley T. (Birkbeck Coll., Univ. London, London WCIE 7HX, UK). Cancer Res., 46(11), 5486-93 (English) 1986. CODEN: CNREA8. ISSN: 0008-5472. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Evaluation of bis[1,2-bis(diphenylphosphino)ethane]gold(I) chloride (I) [19624-67-0] in mice bearing i.p. P388 leukemia demonstrated that the compd. produced an av. of 87% increase in life span at its maximally tolerated dose (2-3 mmol/kg/day for 5 days). Activity was also seen in i. 19624-67-0 and 15663-27-1 which are cas registry numbers are also used here.p. M5076 reticulum cell sarcoma (60% increase in life span) and s.c. mammary adenocarcinoma 16/c. Modest activity was evident in i.p. B16 melanoma and L1210 leukemia. A subline of P388 leukemia resistant to cisplatin [15663-27-1] was not cross-resistant to I. In addn., combination therapy of I and cisplatin against i.p. P388 demonstrated an advantage over single-agent therapy. In vitro studies of I showed that the compd.: (a) is cytotoxic to tumor cell lines; (b) is only minimally inhibited in its cytotoxic activity by the presence of serum; (c) produces DNA protein cross-links and DNA strand breaks in cells; and (d) inhibits macromol. synthesis with a preferential inhibitory effect on protein synthesis relative to DNA and RNA synthesis. 31P NMR spectroscopy indicated that the compd. is stable in the presence of serum proteins, thiols, or disulfides and that it reacts with Cu(II) resulting in the formation of a Cu(I)-bis(diphenylphosphino)ethane complex [1663-45-2]. The results of these in vivo and in vitro expts. suggest that the contrasting pharmacol. profile of I with respect to other gold(I) phosphine complexes may be related to both the kinetic stability of the complex and its stability in the presence of thiols. .

Bond Angle Effects on the Migratory Insertion of Ethylene and Carbon Monoxide into Palladium(II)-Methyl Bonds in Complexes Bearing Bidentate Phosphine Ligands

Bond Angle Effects on the Migratory Insertion of Ethylene and Carbon Monoxide into Palladium(II)-Methyl Bonds in Complexes Bearing Bidentate Phosphine Ligands. Ledford, John; Shultz, C. Scott; Gates, Derek P.; White, Peter S.; DeSimone, Joseph M.; Brookhart, Maurice (Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599-3290, USA). Organometallics, 20(25), 5266-5276 (English) 2001 American Chemical Society. CODEN: ORGND7. ISSN: 0276-7333. DOCUMENT TYPE: Journal CA Section: 29 (Organometallic and Organometalloidal Compounds) Section cross-reference(s): 22, 75 Labile (P-P)Pd(CH3)(OEt2)+BAr'4- complexes (2) have been prepd. via protonation of (P-P)PdMe2 (1), where P-P = cis-1,2-bis(diphenylphosphino)ethylene (a, dppee), 1,2-bis(diphenylphosphino)benzene (b, dpbz), 1,2-bis(diphenylphosphino)ethane (c, dppe), 1,2-bis(dimethylphosphino)ethane (d, dmpe), 1,3-bis(diphenylphosphino)propane (e, dppp), 1,3-bis(diisopropylphosphino)propane (f, dippp), 1,4-bis(diphenylphosphino)butane (g, dppb) and Ar' = 3,5-(CF3)2C6H3. Unstable complex 2d (P-P = dmpe) was generated in situ. X-ray structures are reported for 1e and 2e-g. Treatment of 2a-g with CO in CH2Cl2 at -90° yields the (P-P)Pd(CH3)(CO)+ complexes 3a-g. Barriers to migratory insertion in 3a-g were detd. with the ordering to be: 3f (dippp) u 3g (dppb) < 3e (dppp) ? 3a (dppee) u 3b (dpbz) u 3c (dppe) < 3d (dmpe). Exposure of 2a-g to ethylene at -80° yields the ethylene complexes (P-P)Pd(CH3)(C2H4)+ (5a-g). Barriers to migratory insertion in these complexes were detd. by NMR spectroscopy to be: 5b (dpbz) u 5e (dppp) u 5f (dippp) u 5g (dppb) < 5a (dppee) u 5c (dppe) < 5d (dmpe). Complexes (P-P)Pd(CH2CH3)(C2H4)+ (6a-e,g) produced from 5a-e,g under C2H4 are catalyst resting states for the dimerization of C2H4 to butenes. In the case of 5f (P-P = dippp), the catalyst resting state produced is the b-agostic Et complex (dippp)Pd(CH2CH2-m-H)+ (8f), which has been isolated. This complex exhibits two dynamic processes studied by VT-NMR:interchange of Ca and Cb (DGG = 10.3(2) kcal/mol) and rotation of the agostic Me group (DGG ca. 6.4 kcal/mol). The b-agostic Pr complex 7f has been generated and identified as the Pr isomer (dippp)Pd(CH2CH2-m-HCH3)+. Keywords bond angle effect migratory insertion ethylene carbon monoxide palladium methyl bidentate phosphine complex prepn migratory insertion crystal mol structure methyl palladium bidentate phosphine arylborate complex kinetics migratory insertion ethylene carbon monoxide palladium dimethyl complex Index Entries Bond agostic; bond angle effects on migratory insertion of ethylene and carbon monoxide into palladium-Me bonds in complexes bearing bidentate phosphine ligands Free energy of activation Insertion reaction kinetics Potential barrier bond angle effects on migratory insertion of ethylene and carbon monoxide into palladium-Me bonds in complexes bearing bidentate phosphine ligands Bond carbon-palladium; bond angle effects on migratory insertion of ethylene and carbon monoxide into palladium-Me bonds in complexes bearing bidentate phosphine ligands Bond angle effect; bond angle effects on migratory insertion of ethylene and carbon monoxide into palladium-Me bonds in complexes bearing bidentate phosphine ligands Insertion reaction intramol., migration; bond angle effects on migratory insertion of ethylene and carbon monoxide into palladium-Me bonds in complexes bearing bidentate phosphine ligands Crystal structure Molecular structure of methylpalladium complexes with bidentate phosphine ligands Dimerization catalysts prepn. of methylpalladium bidentate phosphine complexes as dimerization catalysts for alkenes 260994-21-6 389798-51-0 389798-53-2 389798-55-4 389798-57-6 389798-59-8 389798-61-2 74-85-1, reactions 51915-19-6 139362-04-2 15630-15-6 63455-39-0 210767-94-5 288155-73-7 389798-18-9 389798-19-0 389798-21-4 389798-23-6 389798-25-8 389798-27-0 389798-29-2 389798-31-6 389798-33-8 389798-35-0 389798-37-2 389798-39-4 bond angle effects on migratory insertion of ethylene and carbon monoxide into palladium-Me bonds in complexes bearing bidentate phosphine ligands 113530-46-4 113530-47-5 210767-70-7 260993-77-9 crystal structure; bond angle effects on migratory insertion of ethylene and carbon monoxide into palladium-Me bonds in complexes bearing bidentate phosphine ligands 288155-74-8 288155-77-1 389798-41-8 389798-43-0 389798-44-1 389798-45-2 389798-47-4 389798-49-6 389798-63-4 389798-65-6 389798-67-8 389798-69-0 389798-71-4 389798-73-6 389798-75-8 389798-77-0 prepn. of 113822-11-0 reaction with bidentate phosphines 983-80-2 1663-45-2 6737-42-4 7688-25-7 13991-08-7 23936-60-9 91159-11-4 reaction with dimethyl(tetramethylethylenediamine)palladium complex