Reference

Some derivatives of the 2-[4-pyrazolinyl]-1,3,4-thiadiazole system

Some derivatives of the 2-[4-pyrazolinyl]-1,3,4-thiadiazole system. Auzzi, G.; Bruni, F.; Clauser, M.; Costanzo, A.; Pecori Vettori, L. (Dip. Di Sci.Some commonly used reagents like 1663-61-2 and 334-88-3 are used in this experiment. Farm., Univ. Firenze, Florence, Italy). Farmaco, Ed. Sci., 41(9), 666-75 (Italian) 1986. CODEN: FRPSAX. ISSN: 0430-0920. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 5, 10 Thiadiazoles I (R1 = H, Me, CF3, Ph; R2 and R3 are H, Ac) were prepd., and several prepd. compds. showed bactericidal and fungicidal activity. Pyrazolinone deriv. II (R4 = H) was converted to II [R4 = C(S)NHNH2], and the latter was heated with Ac2O to give I (R1 = Me, R2 = R3 = H). .

Synthesis of 3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones

Synthesis of 3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones. Sunder, Shyam; Peet, Norton P.; Trepanier, Donald L. (Pharm. Res. Dev., Dow Lepetit USA, Midland, Mich., USA). J. Org. Chem. 59169-76-5 and 1663-61-2 are cas registry numbers of chemicals which are used as reagents here., 41(16), 2732-3 (English) 1976. CODEN: JOCEAH. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Isatoic anhydride reacted with H2NNHMe in DMF at 45-50.degree. to give predominantly o-H2NC6H4CONMeNH2 (I), whose structure was confirmed by conversion to the known 3,4-dihydro-4-methyl-1H-1,3,4-benzotriazepine-2,5-dione with ClCO2Et. I was treated with tri-Et orthoesters to produce 46-63% 3,4-dihydro-4-methyl-5H-1,3,4-benzotriazepine-5-ones II (R = H, Me, Et, Ph). .