Detail of "1665-56-1"

CAS Number:
1665-56-1
Name:
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-,(4S,4aS,12aS)-
Molecular Structure:
Formula:
C22H22 N2 O7
Molecular Weight:
426.4193
Synonyms:
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-(6CI,7CI,8CI); 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-,[4S-(4a,4aa,12aa)]-; (4S)-Anhydrotetracycline; 5a(6)-Anhydrotetracycline;Anhydrotetracycline; Tetracycline, anhydro-
Density:
1.6 g/cm³
Boiling Point:
618.6 °C at 760 mmHg
Flash Point:
327.9 °C

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Improvement of chemical analysis of antibiotics: Improvement of chemical analysis of antibiotics. III. Simple method for the analysis of tetracyclines on reversed-phase thin-layer plates.Several substances are used for example 564-25-0 and 79-85-6 which are their cas registry numbers. Oka, Hisao; Uno, Keiichi; Harada, Kenichi; Suzuki, Makoto (Aichi Prefect. Inst. Public Health, Nagoya 462, Japan). J. Chromatogr., 284(1), 227-34 (English) 1984. CODEN: JOCRAM. ISSN: 0021-9673. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Tetracyclines and their impurities can be detd. by TLC on C8- and C18-modified silica gel plates using pH 2 MeOH-MeCN-0.5M aq. oxalic acid (1:1:4 and 1:1:2, resp.). The C8 plate and solvent were best for complete sepn. of tetracycline (I) [60-54-8], oxytetracycline [79-57-2], chlortetracycline [57-62-5], and doxycycline [564-25-0] in residue or biol. sample anal. The C18 plate and solvent were best for detg. epitetracycline [79-85-6], anhydrotetracycline [1665-56-1], and 4-epianhydrotetracycline [7518-17-4] impurities in I and chlortetracycline. The compds. are identified by dual-wavelength spectrometry in the reflection mode. Calibration graphs were linear for 0.1-1.0 mg. .

Anhydrotetracycline is a major product of tetracycline photolysis: Anhydrotetracycline is a major product of tetracycline photolysis. Hasan, Tayyaba; Allen, Mark; Cooperman, Barry S. (Dep. Chem., Univ. Pennsylvania, Philadelphia, PA 19104, USA). J. Org. Chem., 50(10), 1755-7 (English) 1985. CODEN: JOCEAH. ISSN: 0022-3263. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) 5A,6-anhydrotetracycline (I) [1665-56-1] was the major product formed when tetracycline [60-54-8] was photolyzed in an aq. buffer (pH 7.6) contg. b-mercaptoethanol. I was isolated by HPLC of the photolysis reaction mixt. and identified by comparison of its spectral and chromatog. properties with authentic anhydrotetracycline. The formation of I is consistent with previous studies of the photoaffinity labeling of Escherichia coli ribosomes by tetracycline and of tetracycline-induced cutaneous phototoxicity.