Detail of "16662-47-8"

Reference

Stimulation of renal gluconeogenesis by verapamil and D-600

Stimulation of renal gluconeogenesis by verapamil and D-600. Gordon, Edwin E.; Ferris, Robert K. (Med. Cent., New York Univ., New York, N. Y., USA). Biochem. Pharmacol., 26(11), 1089-91 (English) 1977. CODEN: BCPCA6. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Exposure of rat kidney tubules to 10-5 or 10-4M verapamil [52-53-9] or d-600 [16662-47-8] for 15 min resulted in an increased rate of gluconeogenesis with either 5 .times. 10-3M succinate [110-15-6] or .alpha.-ketoglutarate [328-50-7]. Neither verapamil or D-600 affected the respiratory rate of tubule prepns. in the presence or absence of Ca2+. Stimulation of gluconeogenesis by 2.5mM Ca2+, 3-fold after 30 min, was increased further by verapamil. Ca2+-induced increases in the Ca2+ content of tubules was unaffected by verapamil, as were Ca2+ losses in the absence of extracellular Ca2+. The verapamil-stimulating mechanism could therefore act independently of the Ca2+ mechanism. In addn., the data support the concept that the rate of gluconeogenesis is not an important determinant of the rate of mitochondrial energy generation.

Calcium-channel blockers and the electrophysiology of synaptic transmission of the guinea pig olfactory cortex

Calcium-channel blockers and the electrophysiology of synaptic transmission of the guinea pig olfactory cortex. Kuan, Y. F.; Scholfield, C. N. (Physiol. Dep., Queen's Univ., Belfast, UK).Some commonly used reagents like 7439-95-4 and 7440-02-0 are used in this experiment. Eur. J. Pharmacol., 130(3), 273-8 (English) 1986. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2, 13 Slices of guinea pig olfactory cortex were used to compare the potency of various Ca2+ blockers on the electrophysiol. of synaptic transmission. Listed in the order of potency, the divalent cations Cd2+, Ni2+, Mn2+, Co2+, La3+, and Mg2+ depressed synaptic transmission. The org. Ca2+-blockers nifedipine [21829-25-4], nimodipine [66085-59-4], (±)-verapamil [56949-77-0], and diltiazem [42399-41-7] were ineffective up to 0.01 mmol/L. Verapamil, D600 [16662-47-8] or diltiazem (0.1-0.3 mmol/L depressed both synaptic transmission and the Na+-mediated presynaptic action potential. Apparently, org. Ca2+ antagonist do not block all Ca2+-channels in brain and the high Cd2+ sensitivity suggests the Ca2+-channels in post- and presynaptic membranes have dissimilar pharmacol. profiles. .