Detail of "16673-34-0"

Reference

Method for preparation of glibenclamide

Method for preparation of glibenclamide.In this study， 16673-34-0 and 33924-49-1 are also used. Hwang, Ui Hyeong; Jang, Hae Seong; Jung, Geun Hoe; Kim, Dae Hwang; Kim, Seon Ok; Ko, Yeong Gwan; Koo, Dong Wan; Ryu, Jae Uk; Woo, Jae Chun (Korea Research Institute of Chemical Technology, S. Korea). Repub. Korean Kongkae Taeho Kongbo KR 2002083568 A 4 Nov 2002, No pp. given (Korean). (Korea, Republic Of). CODEN: KRXXA7. CLASS: ICM: C07C317-32. APPLICATION: KR 2001-22944 27 Apr 2001. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Provided is a method for economically synthesizing glibenclamide, with powder shape, which is used as an intermediate for synthesis of medicine useful for treatment of diabetes. The method comprises the steps of (i) reacting N-phenethyl-5-chloro-2-methoxybenzamide with chlorosulfonic acid(ClSO3H) represented by formula 2 in the presence of thionyl chloride(SOCl2) to form p-(N-phenethyl-5-chloro-2-methoxybenzamide)sulfonylchloride represented by formula 3; (ii) reacting sulfonylchloride compd. represented by formula 3 with ammonia to form p-(N-phenethyl-5-chloro-2-methoxybenzamide)sulfoneamide represented by formula 4; (iii) reacting sulfoneamide compd. represented by formula with alkali metal hydroxide in the presence of alc. solvent to form p-(N-phenethyl-5-chloro-2-methoxybenzamide)sulfone amide-metal salt represented by formula 5; and (iv) reacting the metal represented by formula 5 with cyclohexyl isocyanate or phenylcyclohexyl carbamate to form glibenclamide represented by formula 1. .

Wide concentration range investigation of recovery, precision and error structure in liquid chromatography

Wide concentration range investigation of recovery, precision and error structure in liquid chromatography. [Erratum to document cited in CA]. Schepers, U.; Ermer, J.; Preu, L.; Waetzig, H. (Institute of Pharmaceutical Chemistry, TU Braunschweig, Braunschweig D-38106, Germany).There are some reagents like 16673-34-0 is used in this study. Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences, 828(1-2), 136 (English) 2005 Elsevier B.V. CODEN: JCBAAI. ISSN: 1570-0232. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) On page 113 of the print version, the sentence "The mobile phase (acetonitrile-buffer, , v/v) was prepared by dissolving 650 mg disodium hydrogen phosphate dihydrate in 550.0 g water and adding two drops of phosphoric acid 85% and 351.5 g acetonitrile to 1000 mL followed by degassing it in the ultrasonic bath" should read: "The mobile phase (acetonitrile-buffer, , v/v) was prepared by dissolving 650 mg sodium dihydrogen phosphate dihydrate in 550.0 g water and adding two drops of phosphoric acid 85% and 351. 16673-34-0 is also in the experiment.5 g acetonitrile to 1000 mL followed by degassing it in the ultrasonic bath.". ..