Detail of "1668-19-5"

CAS Number:
1668-19-5
Name:
1-Propanamine,3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-
Molecular Structure:
Formula:
C19H21 N O
Molecular Weight:
279.41
Synonyms:
Dibenz[b,e]oxepin-D11(6H),g-propylamine, N,N-dimethyl-(7CI,8CI); Dibenz[b,e]oxepin, 1-propanamine deriv.;11-[3-(Dimethylamino)propylidene]-6H-dibenz[b,e]oxepin; Doxepin; Doxepine;N,N-Dimethyldibenz[b,e]oxepin-D11(6H),g-propylamine;NSC 108160
Density:
1.122 g/cm³
Melting Point:
187-189°C
Boiling Point:
413.3 °C at 760 mmHg
Flash Point:
121.3 °C
Solubility:
readily soluble in water, lower
Appearance:
white crystalline solid
Safety:
Human poison by ingestion. Experimental poison by ingestion, intravenous, and intraperitoneal routes. A sedative and hypnotic used as an antianxiety agent. When heated to decomposition it emits toxic fumes of NO_x. Details

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Doxepin

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Therapeutic monitoring of tricyclic antidepressants in plasma by gas chromatography: Therapeutic monitoring of tricyclic antidepressants in plasma by gas chromatography. Dorrity, Floyd, Jr.; Linnoila, Markku; Habig, Robert L. (Dep. Psychiatry, Duke Univ. Med. Cent., Durham, N. C., USA). Clin. Chem. (Winston-Salem, N. C.), 23(7), 1326-8 (English) 1977. CODEN: CLCHAU. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) A comprehensive gas chromatog. anal. for therapeutic concns. of amitriptyline (I) [50-48-6], nortriptyline [72-69-5], imipramine [50-49-7], desipramine [50-47-5], doxepin [1668-19-5], and desmethyldoxepin [1225-56-5] in plasma, is described with use of a N detector. All these drugs are extd. and chromatographed under identical conditions. Each tertiary amine tricyclic is well resolved from its secondary amine metabolite on a mixed-phase column and the concns. of both are detd. simultaneously, without derivatization. The lower limit of sensitivity is 10 .mu.g/L of plasma (2-ml sample). Analytical recoveries of the tertiary and secondary amines are 100 and 80%, resp. Between-run CV's for all of the drugs ranged between 5 and 7%.

Interactions of tricyclic antidepressant drugs with deprivation-induced fluid consumption by rats: Interactions of tricyclic antidepressant drugs with deprivation-induced fluid consumption by rats. Zabik, J. E.; Levine, R. M.; Spaulding, J. H.; Maickel, R. P. (Dep. Pharmacol., Indiana Univ., Bloomington, Indiana, USA). Neuropharmacology, 16(4), 267-71 (English) 1977. CODEN: NEPHBW. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Fluid consumption by rats was reduced by desipramine [50-47-5] > amitriptyline [50-48-6] > doxepin [1668-19-5] > nortriptyline [72-69-5] > imipramine [50-49-7] > protriptyline [438-60-8] (5, 10, 20 mg/kg, i.p.). Pretreatment with p-chlorophenylalanine [1991-78-2] (400 mg/kg, i.p.) reduced fluid consumption at 24 h, and levels had not returned to normal in 15 days.