Detail of "16694-46-5"

Reference

Gamma globulin solution suitable for intravenous use

Gamma globulin solution suitable for intravenous use. Stephan, Wolfgang (Biotest-Serum-Institut G.m.b.H., Ger.). Ger. Offen. DE 2614503 13 Oct 1977, 5 pp. Addn. to Ger. Offen. 1,792,555. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K037-06. APPLICATION: DE 76-2614503 3 Apr 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) A std. g-globulin soln. mixed with 0.05 g Et formimidate-HCl (I) [16694-46-5]/g protein at pH 9 and kept at 5° for 2 h gives a suitable i.v. soln. after readjustment to pH 7.5, dialysis, and sterilization. I has the advantage over other previously used compds. of having the smallest mol. wt., so that the immunol. properties of the protein are not changed significantly by the reaction. The treated g-globulin soln. is well tolerated upon long-term administration. Thus, 100 mL of a 5% std. g-globulin soln. was stirred for 2 h at 50 with 0.05 g I/g protein at pH 9; the pH was then adjusted to 7.5 and the soln. dialyzed against physiol. NaCl soln. and sterilized by filtration. The prepn. could be concd. by ultrafiltration or by pptn., such as with alc. or (NH4)2SO4.

Imidazole syntheses, part 13

Imidazole syntheses, part 13. Synthesis of 5(4)-alkyl-substituted 4(5)-bromomethylimidazoles. Lennartz, Hans Gerd; Schunack, Walter (Fachber. Pharm., Univ. Mainz, Mainz, Ger.). Arch.Several substances are used for example 16694-46-5 which is its cas registry number. Pharm. (Weinheim, Ger.), 310(12), 1019-22 (German) 1977. CODEN: ARPMAS. ISSN: 0365-6233. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Imidazoles I (R = Et, Pr, Bu; R1 = OMe) were prepd. by treating RCOCH:CH2 with Hg(OAc)2 and Br to give RCOCHBrCH2OMe, which were treated with HC(:NH)OEt and NH3. Treatment of I (R1 = OMe) with HBr gave I (R1 = Br). .