Detail of "16709-25-4"

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Serotonin synthesis increased in terminals four days after reserpine treatment: an autoradiographic study in rat brain

Serotonin synthesis increased in terminals four days after reserpine treatment: an autoradiographic study in rat brain. Muck-Seler, Dorotea; Diksic, Mirko (Cone Neurosurgical Res.Several substances are used for example 16709-25-4 and 50-67-9 which are their cas registry numbers. Lab., McGill Univ., Montreal, QC H3A 2B4, Can.). Neurochemical Research, 22(1), 11-16 (English) 1997 Plenum. CODEN: NEREDZ. ISSN: 0364-3190. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 The rate of 5-HT synthesis was detd. in discrete rat brain regions 4 days after a single dose of reserpine (10 mg/kg) or reserpine carrier (controls), using an autoradiog. method with labeled a-methyl-L-tryptophan as a tracer. The results show that the rate of 5-HT synthesis was unchanged in the dorsal and median raphe, significantly decreased in the raphe magnus, and significantly increased in areas rich in serotonergic nerve terminals (i.e., hypothalamus, hippocampus, median geniculate body, parietal and visual cortices). An increase in tryptophan hydroxylase activity could account for the increase in the rate of serotonin synthesis seen in some regions. Since the 5-HT synthesis rate showed regional variability there seems to be a need for regional studies of the effect of drugs on the 5-HT synthesis. In addn., the 5-HT synthesis rate was not significantly different from that in controls in many of the brain regions. .