Reference

Effects of Fenoldopam, a dopamine D-1 agonist, and Clevidipine, a calcium channel antagonist, in acute renal failure in anesthetized rats

Effects of Fenoldopam, a dopamine D-1 agonist, and Clevidipine, a calcium channel antagonist, in acute renal failure in anesthetized rats. Stephens, Christopher T.; Jandhyala, Bhagavan S. (Institute for Cardiovascular Studies, College of Pharmacy, University of Houston, Houston, TX 77204, USA). Clinical and Experimental Hypertension, 24(4), 301-313 (English) 2002 Marcel Dekker, Inc. CODEN: CEHYER. ISSN: 1064-1963. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 14 The present studies were conducted to: (1) comparatively, evaluate the effects of Clevidipine, a new dihydropyridine calcium antagonist, and Fenoldopam, a dopamine (D-1) receptor agonist on basal renal function, and (2) to det. the efficacy of these agents in protecting renal function in an exptl. model of ischemia/reperfusion (I/R)-induced acute renal failure in rats. Infusions of either Clevidipine or Fenoldopam (5.0 nmol/kg-1 min-1 i.v. for 60 min) produced significant increases in urine flow (UV), urinary sodium excretion (UNaV), and fractional excretion of sodium (FENa) in Inactin-anesthetized rats. Unlike Clevidipine, Fenoldopam also produced significant increases in renal blood flow (RBF) and urinary potassium excretion (UKV). In a sep. series, unilateral renal failure was induced in anesthetized rats by occluding the left renal artery for 40 min followed by reperfusion. In this model, there was a 70-75% redn. in the GFR that was paradoxically assocd. 67227-56-9 and 167221-71-8 which are cas registry numbers of chemicals are mentioned. with several-fold increases in UV, UNaV, and FENa in the vehicle-treated group. In 2 sep. groups, infusions of neither Clevidipine nor Fenoldopam (5.0 nmol/kg-1 min-1) for 60 min beginning 10 min before reperfusion improved the filtration fraction. However, Clevidipine treatment markedly improved tubular function in that loss of sodium and water were significantly attenuated and UV and UNaV were restored towards basal levels. In contrast, in the Fenoldopam group, tubular function was further deteriorated as evidenced by exacerbated losses of sodium and water. These observations suggest that whereas both Clevidipine and Fenoldopam were potent natriuretic agents, only the calcium antagonist was effective in preserving renal function in the present exptl. model of ischemic renal failure. .