Reference

Chemical studies on tuberactinomycin

Chemical studies on tuberactinomycin. XV. Total synthesis of tuberactinomycin O. Teshima, Tadashi; Nomoto, Shinya; Wakamiya, Tateaki; Shiba, Tetsuo (Fac. Sci., Osaka Univ., Toyonaka, Japan). J. Antibiot., 30(12), 1073-9 (English) 1977. 1676-75-1 which is the cas registry number of some chemical is mentioned. CODEN: JANTAJ. ISSN: 0021-8820. DOCUMENT TYPE: Journal CA Section: 34 (Synthesis of Amino Acids, Peptides, and Proteins) Tuberactinomycin O (I) was prepd. by coupling BOC-b-Lys(BOC)-OSu (BOC = Me3CO2C, Su = succinimido) to tuberactinamine N (II) and BOC-deblocking the resulting III. Dipeptide IV [Nps = o-(O2N)C6H4S, Cpd = capreomycidine residue, A2pr = HNCH(CH2NH2)CO] was coupled to H-Ser(CMe3)-Ser(CMe3)-Dea-OEt [Dea = HNCH[CH(OEt)2]CO] to give the pentapeptide which was sapond. and esterified with HOSu to give pentapeptide active ester V. V was Nps-deblocked with HCl and cyclized with pyridine to give cyclic peptide VI which was deblocked by hydrogenation and CF3CO2H and then the b,b-diethoxyalanine residue was treated with urea to give II. .