Detail of "16773-52-7"

CAS Number:
16773-52-7
Name:
1H-Imidazole,2-methyl-5-nitro-1-(2-oxiranylmethyl)-
Molecular Structure:
Formula:
C7H9 N3 O3
Molecular Weight:
183.1647
Synonyms:
1H-Imidazole,2-methyl-5-nitro-1-(oxiranylmethyl)- (9CI); Imidazole,1-(2,3-epoxypropyl)-2-methyl-5-nitro- (8CI);1-(2,3-Epoxypropyl)-2-methyl-5-nitroimidazole
Density:
1.59g/cm³
Boiling Point:
395.5°Cat760mmHg
Flash Point:
193°C

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Compounds useful in radiotherapy or chemotherapy: Compounds useful in radiotherapy or chemotherapy. Ahmed, Israr; Adams, Gerald Edward; Stratford, Ian James; Gibson, David (National Research Development Corp., UK). Eur. Pat. Appl. EP 95906 A1 7 Dec 1983, 13 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, IT, LI, LU, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: C07D233-91; C07D403-06; A61K031-415; A61K031-41. APPLICATION: EP 83-303063 27 May 1983. PRIORITY: GB 82-15545 27 May 1982; GB 82-31107 1 Nov 1982. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 27 [Aziridinyl(hydroxy)alkyl]imidazoles I (R = NO2, R1 = H, alkyl; R2-R5 = alkyl, aryl, aralkyl, alkaryl; n = 1, 2)], enhancers for neoplasm inhibitors and radiation therapy, were prepd. Thus, aziridine and 1-(2,3-epoxypropyl)-2-nitro-1H-imidazole were refluxed for 1 h in MeOH to give 56% I (R = 2-NO2, R1-R5 = H, n = 1) (II). In mice implanted with MT tumor, 3.8 mg II/kg (i.p.) had an enhancement ratio of 1.7 for radiation treatment and 0.08 mg/kg (i.p.) had an enhancement ratio of 3.0 for chemotherapy with melphalan.Except for chemicals metioned above, 88876-89-5 and 16773-52-7 are also used. .