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Detail of "167933-07-5"

  • CAS Number:
  • 167933-07-5
  • Name:

  • Flibanserin

  • Molecular Structure:
  • Formula:
  • C20H21F3N4O
  • Molecular Weight:
  • 390.40
  • Synonyms:
  • 1-(2-(4-(3-Trifluoromethylphenyl)piperazin-1-yl)ethyl)benzimidazol(1H)-2-one;Bimt 17;1,3-Dihydro-1-(2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl)-2H-benzimidazol-2-one;1-(2-(4-alpha,alpha,alpha-Trifluoro-m-tolyl)-1-piperazinyl)ethyl)-2-benzimidazolinone;Bimt-17;
  • Density:
  • 1.292 g/cm3
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CAS No.167933-07-5 FlibanserinCompetitive Product

  Appearance:white crysta...

Name:Flibanserin Synonyms:3-[2-[4-[4-(Trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one Molecular Formula:C20H21F3N4O Molecular Weight:390.40 CAS No.:167933-07-5 -------More details, pls contact us.

Supplier:Tocopharm Co., Ltd. [ China (Mainland)]

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CAS No.167933-07-5 FlibanserinCompetitive Product

FLIBANSERIN

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CAS No.167933-07-5 FlibanserinCompetitive Product

Flibanserin

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CAS No.167933-07-5 FlibanserinCompetitive Product

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CAS No.167933-07-5 Flibanserin

Assay:99%

Flibanserin

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CAS No.167933-07-5 Flibanserin

Flibanserin

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CAS No.167933-07-5 Flibanserin

Flibanserin

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CAS No.167933-07-5 Flibanserin

Assay:more than 99...

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CAS No.167933-07-5 Flibanserin

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CAS No.167933-07-5 Flibanserin

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CAS No.167933-07-5 Flibanserin

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CAS No.167933-07-5 Flibanserin

Flibanserin

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CAS No.167933-07-5 Flibanserin

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CAS No.167933-07-5 Flibanserin

Flibanserin CAS: 167933-07-5 Structure: Molecular Formula: C20H21F3N4O Molecular Weight: 390.4021 Appearance: white powder Assay: 99% Application: pharmaceutical intermediates Improve the female's sexual desire and sex drive

Min. Order:10Gram USD:100- /Gram

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CAS No.167933-07-5 Flibanserin

S/N: BTO-1002 Chemical name: 3-[2-[4-[4-(Trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one CAS Number: 167933-07-5 Synonyms: 3-[2-[4-[4-(Trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one; 1-(2-{4-[4-(trifluoromethyl)phenyl]piperazin-1-yl}eth

Supplier:Wuhan Better Organic Technology Inc [ China (Mainland)]

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CAS No.167933-07-5 Flibanserin

99%

Supplier:Shanghai Huiku biology Technology Co., Ltd [ China (Mainland)]

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CAS No.167933-07-5 Flibanserin

C20H21F3N4O

Supplier:INTERCHEMLTDA [ Colombia]

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CAS No.167933-07-5 Flibanserin

C20H21F3N4O

Supplier:THE TRINITY PHARMACEUTICALS (INDIA) PVT. LTD [ India]

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CAS No.167933-07-5 Flibanserin

C20H21F3N4O

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CAS No.167933-07-5 Flibanserin

C20H21F3N4O

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CAS No.167933-07-5 Flibanserin

C20H21F3N4O

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CAS No.167933-07-5 Flibanserin

C20H21F3N4O

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CAS No.167933-07-5 Flibanserin

C20H21F3N4O

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CAS No.167933-07-5 Flibanserin

C20H21F3N4O

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CAS No.167933-07-5 Flibanserin

C20H21F3N4O

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CAS No.167933-07-5 Flibanserin

C20H21F3N4O

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Reference

Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain
Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain. Marazziti, Donatella; Palego, Lionella; Giromella, Annalisa; Mazzoni, Maria Rosa; Borsini, Franco; Mayer, Norbert; Naccarato, Antonio Giuseppe; Lucacchini, Antonio; Cassano, Giovanni Battista ( Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologia, Universita di Pisa, Pisa 56100, Italy). International Journal of Neuropsychopharmacology, 5(2), 131-140 (English) 2002 Cambridge University Press. CODEN: IJNUFB. ISSN: 1461-1457. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The mode of action of antidepressant drugs may be related to mechanisms of receptor adaptation, involving overall the serotonin 1A (5-HT1A) receptor subtype. However, so far, the clin. effectiveness of selective compds. acting at this level has proved disappointing. This could be explained by the heterogeneity of 5-HT1A receptors within the central nervous system. In animals, two 5-HT1A agonists, flibanserin and buspirone, have shown different pharmacol. properties, depending on the brain region. Since no evidence supports this observation in humans, this study sought to investigate whether these two drugs exert different effects on 5-HT1A receptor activation in three different human brain areas: the prefrontal cortex, hippocampus and raphe nuclei. 5-HT1A-mediated inhibition of forskolin-stimulated adenylyl cyclase (AC) was taken as an index of 5-HT1A receptor activation. Flibanserin significantly reduced the activity of AC post-synaptically, i.e. in the prefrontal cortex [EC50 (mean ± S.E.M.Several substances with their cas registry numbers 36505-84-7 and 167933-07-5 may be metioned in this study.), 28 ± 10.2 nM; Emax, 18 ± 2.3%] and in the hippocampus (EC50 3.5 ±3.1 nM; Emax, 20 ± 4.0%), but had no effect in the raphe nuclei, i.e. at pre-synaptic level. Vice versa, buspirone was only slightly but significantly effective in the raphe (EC50, 3.0 ± 2.8 nM; Emax, 12 ± 1.9%). Agonist effects were sensitive to the 5-HT1A antagonists WAY-100135 and pindobind 5-HT1A in the cortex and raphe nuclei, whereas buspirone antagonized flibanserin in the hippocampus. These findings suggest a region-related action of flibanserin and buspirone on forskolin-stimulated AC activity in human brain. .
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