Detail of "16846-24-5"

Reference

Effects of macrolide antibiotics on barbiturate sleeping time in mice

Effects of macrolide antibiotics on barbiturate sleeping time in mice.Some chemicals with cas registry numbers like 76-74-4 and 8025-81-8 are also used. Descotes, J.; Evreux, J. Cl. (Lab. Pharmacol., Fac. Med. Alexis Carrel, Lyon F-69008, Fr.). Experientia, 39(12), 1389-90 (English) 1983. CODEN: EXPEAM. ISSN: 0014-4754. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Triacetyloleandomycin [2751-09-9] and josamycin [16846-24-5], when administered to inbred Balb/c mice orally twice daily at a dose of 12.5 or 25 mg/kg over 3 days, increased barbiturate sleeping time significantly. In contrast, erythromycin ethylsuccinate [1264-62-6], erythromycin propionate [134-36-1], midecamycin [35457-80-8], and spiramycin [8025-81-8] were devoid of any such activity under the same conditions. The relationship of these results to the effect of macrolide antibiotics on drug-metabolizing enzymes and their drug-drug interactions are discussed. .

Studies on clinical pharmacology

Studies on clinical pharmacology. XIII. Influence of antibiotics on antiedematigenous and antihistaminic activities of antiinflammatory drugs in simultaneous administration. Fujii, A.; Yoshizawa, M.; Mizuno, S.; Tamura, T. (Sch. Dent., Nihon Univ., Matsudo, Japan). Recent Adv.In this article, certain chemicals are used. Some of their cas registry numbers are 15686-71-2 and 22204-53-1 Chemother., Proc. Int. Congr. Chemother., 14th, Issue Antimicrobial Sect. 1, 679-80. Edited by: Ishigami, Joji. Univ. Tokyo Press: Tokyo, Japan. (English) 1985. CODEN: 55GNAX. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) Simultaneous administration of antibiotics (ampicillin [69-53-4], talampicillin [47747-56-8], bacampicillin [50972-17-3], cephalexin [15686-71-2], and josamycin [16846-24-5]) and nonsteroidal antiinflammatory drugs (aspirin [50-78-2], fenoprofen Ca [34597-40-5], naproxen [22204-53-1], and indomethacin [53-86-1]) increased or slightly decreased antiedematigenous and antihistaminic activities of some antibiotics and antiinflammatory drugs in vivo and in vitro. Talampicillin and bacampicillin, prodrugs of ampicillin, possessed synergistic actions on both activities with antiinflammatory drugs. .