Reference

Branched amides of L-aspartyl-D-amino acid dipeptides

Branched amides of L-aspartyl-D-amino acid dipeptides.Some chemicals with cas registry numbers like 64273-88-7 are also used. Brennan, Thomas M.; Hendrick, Michael E. (Pfizer Inc., USA). U.S. US 4411925 A 25 Oct 1983, 50 pp. Cont.-in-part of U.S. Ser. No. 113,800, abandoned. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A23L001-236. NCL: 426548000. APPLICATION: US 80-201745 5 Nov 1980. PRIORITY: US 80-113800 21 Jan 1980. DOCUMENT TYPE: Patent CA Section: 17 (Food and Feed Chemistry) L-Aspartyl-D-amino acid dipeptide amides are synthesized and used as sweetening agents for food. Thus, b-methyl-N-benzyloxycarbonyl-L-aspartyl-D-alanine (I) [80863-54-3] was prepd. by reacting D-alanine [338-69-2] with b-methyl-L-aspartic acid-HCl [16856-13-6] and benzyloxycarbonyl chloride [501-53-1] after silylation of the D-alanine. I was then reacted with cis-trans-2,6-dimethylcyclohexylamine [24217-12-7] to form b-methyl-N-benzyloxycarbonyl-L-aspartyl-D-alanine N-(cis,trans-2,6-dimethylcyclohexyl)amide [80864-02-4]. This was hydrogenated to L-aspartyl-D-alanine N-(cis,trans-2,6-dimethylcyclohexyl)amide [80863-55-4]. The latter compd., when added to a cola beverage flavoring material at 0.18%, imparted sweetness equiv. to 11% sucrose. .