Detail of "1687-30-5"

Reference

Transparent medical tubes for blood transportation prepared from PVC and di(isononyl)-cyclohexane-1,2-dicarboxylate as plasticizer

Transparent medical tubes for blood transportation prepared from PVC and di(isononyl)-cyclohexane-1,2-dicarboxylate as plasticizer. Heinlein, Martin; Kuehlein, Georg (Rehau AG & Co., Germany). Eur. Pat. Appl. EP 1393759 A1 3 Mar 2004, 8 pp. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT, IE, SI, LT, LV, FI, RO, MK, CY, AL, TR, BG, CZ, EE, HU, SK. (German). (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: A61L033-06. ICS: A61L029-04. APPLICATION: EP 2003-17808 5 Aug 2003. PRIORITY: DE 2002-10239737 29 Aug 2002. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 38 The invention concerns plasticized PVC for medical use that contain 1,2-Cyclohexanedicarboxylic acid, diisononyl ester (Hexamoll DINCH) as plasticizer to achieve Shore hardness A65-A87. A typical formulation includes (parts): PVC 100; di(isononyl)-cyclohexane-1,2-dicarboxylate 35-75; calcium stearate 0.05-0.4; zinc stearate 0.05-0.5; epoxylated vegetable oils 10-18; amide wax 0.5-1.5. Transparent tubes are prepd. for the transportation of blood. The compns. are mixed at 165-180°C and extruded at 150 bar.

Spin labeling studies of the interaction of dicarboxylic acid neurotoxins with human erythrocyte membranes

Spin labeling studies of the interaction of dicarboxylic acid neurotoxins with human erythrocyte membranes. IV: Effects of maleic, succinic, fumaric, and cyclic non-aromatic acids. Butterfield, D. Allan; Wyse, Joseph W.; Abbott, Vicki L.; Nonneman, Arthur J. (Dep. Chem., Univ. Kentucky, Lexington, KY 40506, USA). Biochem. Arch., 2(4), 245-52 (English) 1986. CODEN: BIAREM. ISSN: 0749-5331. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) ESR investigations of the effects of various simple dicarboxylic acid neurotoxic compds. on the phys. state of membrane proteins in human erythrocytes were performed. Previous morphol. and spin labeling studies of quinolinic acid and monopotassium phthalate showed that both were neurotoxic in adult rat brain hippocampus and both altered the conformation and/or organization of erythrocyte membrane proteins. The presence of the adjacent dicarboxylic acid groups of these arom. compds. was found necessary for their neurotoxicity and membrane protein-altering capability. The simplest dicarboxylic acid component of phthalic acid contg. an unsatd. Ca-Ca bond is maleic acid [110-16-7]. To learn more of the effect of phthalic acid on membrane proteins, maleic acid, its trans-isomer (fumaric acid [110-17-8]), its satd. analog (succinic acid [110-15-6]), and cyclic nonarom. counterparts to quinoline and phthalic acid (2,3-piperidine dicarboxylic acid [17079-18-4] and 1,2-cyclohexanedicarboxylic acid [1687-30-5], resp.) were incubated with membranes and the effects on ghost proteins monitored by spin labeling methods. The results indicated that these aliph. dicarboxylic acids, which in sep. studies were subsequently shown to be neurotoxic, produced highly significant alterations in the phys. state of membrane proteins. Both cyclic, nonarom. compds. also produced significant changes in membrane proteins but the Ni-contg. compd. led to membrane protein alterations that were significantly less than those produced by 1,2-cyclohexanedicarboxylic acid. These results are discussed in relation to the membrane-altering and neurotoxic effects of quinolinic and phthalic acids and are suggested to be different than those of the latter arom. neurotoxins.