Detail of "169454-13-1"
- CAS Number:
- 169454-13-1
- Name:
Benzothiazolium,2,2'-[1,3-propanediylbis[(dimethyliminio)-3,1-propanediyl-1(4H)-pyridinyl-4-ylidenemethylidyne]]bis[3-methyl-,iodide (1:4)
- Molecular Structure:
![Molecular Structure of 169454-13-1 (Benzothiazolium,2,2'-[1,3-propanediylbis[(dimethyliminio)-3,1-propanediyl-1(4H)-pyridinyl-4-ylidenemethylidyne]]bis[3-methyl-,iodide (1:4))](http://www.lookchem.com/300w/2010/076/169454-13-1.jpg)
- Formula:
- C41H54 N6 S2 . 4 I
- Molecular Weight:
- 1202.6555
- Synonyms:
- Benzothiazolium,2,2'-[1,3-propanediylbis[(dimethyliminio)-3,1-propanediyl-1(4H)-pyridinyl-4-ylidenemethylidyne]]bis[3-methyl-,tetraiodide (9CI); BOBO 1
- Density:
- g/cm3
- Boiling Point:
- °Cat760mmHg
- Flash Point:
- °C
Benzothiazolium,2,2'-[1,3-propanediylbis[(dimethyliminio)-3,1-propanediyl-1(4H)-pyridinyl-4-ylidenemethylidyne]]bis[3-methyl-,iodide (1:4)
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Reference
- Characterization of DNA/lipid complexes by fluorescence resonance energy transfer
- Characterization of DNA/lipid complexes by fluorescence resonance energy transfer. Madeira, Catarina; Loura, Luis M. S.; Aires-barros, M. Raquel; Fedorov, Aleksander; Prieto, Manuel (Instituto Superior Tecnico, Centro de Engenharia Biologica e Quimica, Lisbon, Port.). Biophysical Journal, 85(5), 3106-3119 (English) 2003 Biophysical Society. CODEN: BIOJAU. ISSN: 0006-3495. DOCUMENT TYPE: Journal CA Section: 9 (Biochemical Methods) Section cross-reference(s): 6 Fluorescence resonance energy transfer (FRET) is a potential method for the characterization of DNA-cationic lipid complexes (lipoplexes). In this work, we used FRET models assuming a multilamellar lipoplex arrangement. The application of these models allows the detn. of the distance between the fluorescent intercalator on the DNA and a membrane dye on the lipid, and/or the evaluation of encapsulation efficiencies of this liposomal vehicle. The expts. were carried out in 1,2-dioleoyl-3-trimethylammonium-propane/pUC19 complexes with different charge ratios. We used 2-(3-(diphenylhexatrienyl)propanoyl)-1-hexadecanoyl-sn-glycero-3-phos phocholine (DPH-PC) and 2-(4,4-difluoro-5-octyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1- hexadecanoyl-sn-glycero-3-phosphocholine (BODIPY-PC) as membrane dyes, and ethidium bromide (EtBr) and BOBO-1 as DNA intercalators. In cationic complexes (charge ratios (+/-) 3 2), we verified that BOBO-1 remains bound to DNA, and FRET occurs to the membrane dye. 132172-61-3 and 169454-13-1 are also in the experiment. This was also confirmed by anisotropy and lifetime measurements. In complexes with all DNA bound to the lipid (charge ratio (+/-) = 4), we detd. 27 ? as the distance between the donor and acceptor planes (half the repeat distance for a multilamellar arrangement). In complexes with DNA unbound to the lipids (charge ratio (+/-) = 0.5 and 2), we calcd. the encapsulation efficiencies. The presented FRET methodol. is, to our knowledge, the first procedure allowing quantification of lipid-DNA contact. .