Detail of "17021-26-0"

Reference

The effect of 7

The effect of 7.beta.,17.alpha.-dimethyltestosterone (calusterone) on testosterone metabolism in women with advanced breast cancer. Zumoff, Barnett; Levin, Joseph; Bradlow, H. Leon; Hellman, Leon (Inst. Steroid Res., Montefiore Hosp. Med. Cent., Bronx, N. Y., USA). J. Clin. Endocrinol. Metab., 44(6), 1203-5 (English) 1977. CODEN: JCEMAZ. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 14 Calusterone (I) [17021-26-0] is a 17-alkylated, orally active androgenic steroid used in the treatment of breast cancer. The effect of I on the metab. of 14C-labeled testosterone (II) [58-22-0] and the excretion of endogenous urinary androgen metabolites was studied in 4 patients with breast cancer. Total glucuronide metabolites of the tracer decreased, the androsterone [53-41-8], etiocholanolone [53-42-9] ratio rose by a factor of 2-4, and there was increased formation of uncharacterized polar metabolites. There was no change in either the sum of the excretion of endogenous androgen metabolites or the androsterone/etiocholanolone ratio. Apparently, the effects of I on II metab. represent nonspecific effects of an orally administered 17-alkylated steroid on hepatic structure and function, and probably bear no relation to its therapeutic effect in breast cancer.