Detail of "17146-95-1"

CAS Number:
17146-95-1
Name:
PENTAZOCINE LACTATE
Formula:
C₁₉H₂₇NO•C₃H₆O₃
Molecular Weight:
375.56
Hazard Symbols:
A poison. A human skin irritant.
Safety:
A poison by intraperitoneal route. Human systemic effects. A human skin irritant. When heated to decomposition it emits toxic vapors of NO_x. Details

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Effects of pentazocine on the guinea pig ileum: Effects of pentazocine on the guinea pig ileum. Onuaguluchi, G.; Igwe, S. A. (Coll. Med., Univ. Nigeria, Enugu, Nigeria). Arch. Int. Pharmacodyn. Ther., 284(2), 193-200 (English) 1986. CODEN: AIPTAK. ISSN: 0003-9780. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The pA2 (neg. log of the concn. that produces a half-maximal antagonist effect) values of pentazocine lactate [17146-95-1] for the antagonism of the contraction of the guinea pig ileum induced by acetylcholine (Ach) [51-84-3], 5-HT [50-67-9], and histamine [51-45-6] were 8.0, 7.92 and 7.08, resp. When the effects of a const. dose of pentazocine on equipotent doses of Ach, histamine, 5-HT, and nicotine [54-11-5] were studied, its anti-5-HT and anti-Ach activities were equal and about 6.3 times higher than its antihistamine activity, but were 0.68 times lower than its anti-nicotine activity. The antihistamine activity of pheniramine was 794 times that of pentazocine, whereas the anti-Ach activity of atropine, the anti-5HT activity of cyproheptadine, and the antinicotine activity of hexamethonium were 20, 10, and 2.2 times, resp., higher than that of pentazocine.

Effects of pentazocine on the intestine and biliary tract of the rabbit in vitro: Effects of pentazocine on the intestine and biliary tract of the rabbit in vitro. Tonini, M.; Lecchini, S.; Frigo, G. M.; Crema, A. (Inst. Med. Pharmacol., Univ. Pavia, Pavia, Italy). Naunyn-Schmiedeberg's Arch. Pharmacol., 299(3), 207-10 (English) 1977. CODEN: NSAPCC. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Pentazocine lactate (I lactate) [17146-95-1] impaired peristaltic activity and relaxed longitudinal muscle in the colon and in the ileum isolated from rabbits. The circular coat was excited in the colon, while in the ileum I exhibited both excitatory and inhibitory effects depending on the concn. employed. I did not exert a spasmogenic effect in the smooth muscle of terminal bile duct but instead reduced the elec.-induced contraction. The effect of I does not seem to involve endogenous acetylcholine or catecholamine release.