Reference

Is Sildenafil Citrate an Alternative Agent in the Evaluation of Penile Vascular System with Color Doppler Ultrasound?

Is Sildenafil Citrate an Alternative Agent in the Evaluation of Penile Vascular System with Color Doppler Ultrasound?. Erdogru, Tibet; Usta, Mustafa F.; Ceken, Kagan; Koeksal, Tuerker; Ates, Mutlu; Kabaalioglu, Adnan; Baykara, Mehmet (Department of Urology, Akdeniz University Faculty of Medicine, Antalya, Turk.). Urologia Internationalis, 68(4), 255-260 (English) 2002 S. Karger AG. CODEN: URINAC. ISSN: 0042-1138. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Introduction: The ideal diagnosis and therapeutic agent for erectile dysfunction (ED) would be an oral drug taken prior to color Doppler ultrasound (CDU) examn. and sexual intercourse. In the present study we have investigated if the efficacy of oral sildenafil is optimal in the diagnosis of underlying pathol.Some commonly used reagents like 171599-83-0 and 58-74-2 are used in this experiment. of ED. Material and Methods: The study group comprised of 41 patients with ED. Firstly, all patients underwent CDU examns. after the combined intracavernosal injection of 60 mg of papaverine and sexual stimulation (CIS). Secondly, these patients were examd. after taking 50 mg of oral sildenafil citrate combined with self-manual and visual sexual stimulation. Results: The differences of peak systolic velocity values were statistically significant between CIS and sildenafil (right: 40.7±2.9 vs. 28.7±3.3; left: 41.2±3.3 vs. 25.7±2.4; p < 0.001) in patients with normal penile vascular system. However, end-diastolic velocity and resistance index values were not significant between the same groups. In addn., there were not significant differences for peak systolic and end-diastolic blood flow velocities and resistances index with CIS and sildenafil in cases with vasculogenic ED. Conclusions: Sildenafil citrate plus visual sexual stimulation is not reliable as CIS to make accurate interpretation of penile vascular status using CDU. In some cases suspected of psychogenic ED after detailed sexual history, sildenafil might be tried as an initial step of the functional evaluation with CDU to prevent prolonged erection risk with intracavernosal injection of vasoactive agents. .

Effects of Sildenafil Citrate (Viagra) on Renal Arteries: An Evaluation with Doppler Ultrasound

All Rights Reserved. Effects of Sildenafil Citrate (Viagra) on Renal Arteries: An Evaluation with Doppler Ultrasound. Degirmenci, Bumin; Acar, Murat; Albayrak, Ramazan; Haktanir, Alpay; Yucel, Aylin; Gecici, Omer (Department of Radiology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turk.). 9068-52-4 and 171599-83-0 are also occured in this study. Urologia Internationalis, 77(2), 170-172 (English) 2006 S. Karger AG. CODEN: URINAC. ISSN: 0042-1138. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Introduction: We aimed to det. hemodynamic alterations in renal arteries that may have resulted from oral intake of sildenafil citrate in healthy volunteers. Twelve healthy volunteers were included in our study. Renal Doppler ultrasonog. (US) was performed before the drug intake to assess the basal values. Maximum peak systolic velocity, and resistivity and pulsatility indexes were measured from the segmental branches of both renal arteries in all the examns. After the basal measurements 50 mg of sildenafil or placebo were randomly given to the 12 subjects. Renal Doppler US examns. were carried out 1 h after sildenafil or placebo intake. On the following day sildenafil was administered to the subjects who had previously taken placebo or vice versa. Renal Doppler US was repeated after 1 h. The effect of sildenafil on renal vascular hemodynamics was evaluated by comparison of basal values with post-placebo and post-sildenafil values. No statistically significant differences were found between the basal values of bilateral renal arteries and max. peak systolic velocity, and resistivity and pulsatility index values measured after the placebo or sildenafil intake. We demonstrated that single-dose sildenafil did not cause any significant effect on renal artery hemodynamics in healthy individuals. .