CAS No.1717-59-5,2-(Fluorosulfonyl)difluoroacetic acid Suppliers

Detail of "1717-59-5"

CAS Number:

1717-59-5

Name:

2-(Fluorosulfonyl)difluoroacetic acid

Molecular Structure:

Formula:

C₂HF₃O₄S

Molecular Weight:

178.09

Synonyms:

Aceticacid, difluoro(fluorosulfonyl)- (6CI,7CI,8CI,9CI);(Fluorosulfonyl)difluoroacetic acid;2,2-Difluoro-2-(fluorosulfonyl)aceticacid;2-(Fluorosulfonyl)-2,2-difluoroacetic acid;Difluoro(fluorosulfonyl)acetic acid;

Density:

1.902 g/cm³

Boiling Point:

197.8 °C at 760 mmHg

Flash Point:

73.4 °C

Hazard Symbols:

Risk Codes:

Safety:

26-27-36/37/39 Details

Transport Information:

UN 1760 8/PG 2

Reference

Preparation of heteroaryl benzamide derivatives as glucokinase activators for the treatment of diabetes: All Rights Reserved. Preparation of heteroaryl benzamide derivatives as glucokinase activators for the treatment of diabetes. McKerrecher, Darren; Pike, Kurt Gordon; Waring, Michael James ( Astrazeneca AB; Astrazeneca UK Limited, Swed.). PCT Int. Appl. WO 2007007042 A1 18 Jan 2007, 62pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2006-GB2472 3 Jun 2006. PRIORITY: GB 2005-14174 9 Jul 2005; GB 2005-16298 9 Aug 2005. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Title compds. I [R1 = fluoromethoxymethyl, difluoromethoxymethyl or trifluoromethoxymethyl; R2 = -C(O)NR4R5, -SO2NR4R5, -S(O)pR4, etc.; Het-1 = 5- or 6-membered, C-linked heteroaryl ring contg. a nitrogen atom in the 2-position and optionally 1 or 2 further ring heteroatoms selected from O, N and S, which ring is optionally substituted on an available carbon atom, or on a ring nitrogen atom provided it is not thereby quaternized, with 1 or 2 substituents selected from R6; R3 = halo; R4 = H, alkyl [optionally substituted by 1 or 2 substituents selected from -OR5, -SO2R5, cycloalkyl (optionally substituted by R7)], etc.; R5 = H, alkyl; R4 and R5 together with the nitrogen atom to which they are attached may form a heterocycle; R6 = alkyl, hydroxyalkyl, alkocyalkyl, etc.Several substances with their cas registry numbers 919492-76-5 and 1717-59-5 may be metioned in this study.; R7 = alkyl, -C(O)alkyl, alkoxyalkyl, etc.; p = 0-2; n = 0-2] or their salts were prepd. For example, reaction of 3-([(1S)-2-[(difluoromethyl)oxy]-1-methylethyl]oxy)-5-hydroxy-N-(1-methyl -1H-pyrazol-3-yl)benzamide, e.g., prepd. from Me 3,5-dihydroxybenzoate in 9 steps, with 1-(3-chloro-4-fluorobenzoyl)azetidine afforded compd. II. Compds. of the invention generally activated glucokinase with an EC50 of less than about 500 nM, e.g., compd. II exhibited the EC50 value of 40 nM. .

Detail of "1717-59-5"

2-(Fluorosulfonyl)difluoroacetic acid

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CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

CAS No.1717-59-5 2-(Fluorosulfonyl)difluoroacetic acid

Reference