Reference

Migration of amphetamine and mandelic and salicylic acids in various pH buffer solutions examined via thin layer electrophoresis

Migration of amphetamine and mandelic and salicylic acids in various pH buffer solutions examined via thin layer electrophoresis. Choulis, Nicolas H.; McQuade, Mary S.; Choulis, Marcia (Sch. Pharm., West Virginia Univ., Morgantown, W. Va., USA). Pharmazie, 31(6), 381-2 (English) 1976. CODEN: PHARAT. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Electrophoresis was used to sep. optically active (+)-mandelic acid [(+)-I] [17199-29-0] (-)-I [611-71-2], (.+-.)-I [611-72-3], and optically inactive salicylic acid [69-72-7] and bases (+)-amphetamine [(+)-II] [51-64-9] and (-)-II [156-34-3], using cellulose [9004-34-6], silica gel, and Al2O3 thin layers with various buffer solns. (pH 3.6; 7.0; 9.1). No differences in migratory rate was noted between the 3 forms of I at various pH values (to anode). Salicylic acid moved at a lower rate. II in both forms moved at the same rate to the cathode. With a cellulose layer, at pH 7, all compds. migrated at a faster rate compared with pH 3.6 and 9.1, with the greatest resistance to movement at 9.1. However, with silica gel, migration at pH 7 was slower than at 3.In this experiment, several chemicals are used like 611-72-3 and 69-72-7 6 or 9.1. Similarly using Al2O3 layer, I was slower and II faster. .

Towards chiral TLC plates: some preliminary studies

Towards chiral TLC plates: some preliminary studies. Wilson, Ian D. (Dep. Drug Metab., Hoechst Pharm. Res. Lab., Milton Keynes/Bucks. MK7 7AJ, UK). Methodol.Some commonly used reagents like 611-71-2 and 804-63-7 are used in this experiment. Surv. Biochem. Anal., 16(Bioact. Analytes, Incl. CNS Drugs, Pept., Enantiomers), 277-81 (English) 1986. CODEN: MSBADU. ISSN: 0748-6715. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Chiral stationary phases for TLC plates were tested for resoln. of some racemic mixts. C-18 bonded plates treated with a soln. of Cu acetate followed by (2S,4R,2'RS)-4-hydroxy-1-(2-hydroxydodecyl)proline [90898-50-3] gave poor results for b-blockers but better results with isoxepac [55453-87-7] (optically inactive) and its propionic acid analog [64088-79-5]. An aminopropyl silanized silica gel TLC plate coated with (R)-N-(3,5-dinitrobenzoyl)phenylglycine [74927-72-3] became discolored so no further tests were attempted. Sepn. of D- [611-71-2] and L-mandelic acid [17199-29-0] using quinine sulfate [804-63-7] as ion pair reagent gave slight sepn. and D-camphorsulfonic acid [3144-16-9] no sepn. b-Cyclodextrin [7585-39-9], double-coated plates gave some sepn. of mandelic acids but none for b-blockers. .