Reference

Inhibition of intrathecally administered picrotoxin- and bicuculline-induced convulsions in mice by pipecolic acid or GABA

Inhibition of intrathecally administered picrotoxin- and bicuculline-induced convulsions in mice by pipecolic acid or GABA. Beitz, Alvin J.; Larson, Alice A. (Dep. Vet. Biol., Univ. Minnesota, St. Paul, MN 55108, USA). Eur. J. Pharmacol., 114(2), 181-7 (English) 1985. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 1 Intrathecal injections of picrotoxin and bicuculline in mice produced convulsions which were characterized by a rapid onset and short duration. Coadministration of GABA [56-12-2] with either bicuculline or picrotoxin, but not strychnine, attenuated the severity of the convulsions. Intrathecal injections of DL-pipecolic acid (PA) [4043-87-2] also produced a dose-related increase in the latency to the onset of these convulsions as well as a decrease in their duration; however PA failed to inhibit the duration of strychnine-induced seizures. The D-isomer of PA [1723-00-8] was more effective than the L-isomer [3105-95-1] as an anticonvulsant. When administered in a high dose (500 mg intrathecally), the D- isomer produced flaccid paralysis whereas injection of high doses (100-500 mg, intrathecally) of the L-isomer actually elicited convulsions. These results further support an interaction between PA and GABAergic activity.

D-Pipecolic acid inhibits ethanol tolerance in mice

D-Pipecolic acid inhibits ethanol tolerance in mice. Szabo, Gyula; Kovacs, Gabor L.; Balaspiri, Lajos; Telegdy, Gyula (Med. Sch., Univ. Szeged, Szeged, Hung.). Neurochem. Res., 11(12), 1677-82 (English) 1986. CODEN: NEREDZ. ISSN: 0364-3190. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The effects were studied of graded doses of D-pipecolic acid (I) [1723-00-8] (0.005-5 mg/mouse, s.c.) on tolerance to the hypothermic effect of EtOH [64-17-5] (4 g/kg, i.p.). I itself did not change the core temp. or the acute hypothermic response to a single dose of EtOH. Repeated I administration, however, blocked the development of tolerance to the hypothermic effect of EtOH. The development of tolerance could be obsd. in the control group. It is assumed that I is capable of counteracting the tolerance effect of EtOH.