Reference

Mechanism of antiprogestational action of danazol

Mechanism of antiprogestational action of danazol. Tamaya, Teruhiko; Furuta, Norio; Nioka, Suminori; Boku, Shinko; Shimura, Tatsuoki; Okada, Hiroji (Dep. Obstet. Gynecol., Kyoto Prefect. Univ. Med., Kyoto, Japan). Sanfujinka No Shimpo, 29(3), 243-9 (Japanese) 1977. CODEN: SASHA5. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) The McGinty test demonstrated the inhibitory effect of danazol (I) [17230-88-5] on progestational proliferation. I inhibited the progesterone [57-83-0] binding to 8S macromols. binding in a sedimentation profile. The I-receptor complex entered into the uterine nucleus less than did progesterone-receptor complexes. Progesterone-receptor complexes activated the uterine chromatin template but the I-receptor complex did not. I was bound to progesterone receptors in the cytoplasm and entered into the nucleus, but the I-receptor complex did not activate the chromatin template.

Danazol as a luteolytic agent

Danazol as a luteolytic agent. Wentz, Ann Colston; Sapp, Karan C. (Dep. Gynecol. Obstet., Johns Hopkins Univ. Sch. Med., Baltimore, Md., USA). Fertil. Steril., 29(1), 23-5 (English) 1978. CODEN: FESTAS. ISSN: 0015-0282. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Danazol (I) [17230-88-5] was administered to healthy nonpregnant volunteers to det. whether a luteolytic effect could be detected by observation of cycle length, duration of the luteal rise, and luteal steroidogenesis. I resulted in a decreased duration of the luteal rise and decreased progesterone [57-83-0] output in 3 of 4 subjects, but did not decrease total cycle length. The administration of human chorionic gonadotropin during I administration increased progesterone output. Therefore, I would apparently be ineffective as a leuteolytic contraceptive agent.