CAS No.17321-77-6,Clomipramine hydrochloride Suppliers

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Basic Information

Molecular Structure:
CAS No.:	17321-77-6
Name:	Clomipramine hydrochloride
Article Data:	3

Formula:	C₁₉H₂₃ClN₂.HCl
Molecular Weight:	351.319
Synonyms:	5H-Dibenz[b,f]azepine,3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-, monohydrochloride (8CI);5H-Dibenz[b,f]azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl-,monohydrochloride (9CI);3-Chloro-5-(3-dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepinehydrochloride;3-Chloroimipramine hydrochloride;Anafranil;Anaphranil;Anatranil;Chloroimipramine monohydrochloride;
EINECS:	241-344-3
Melting Point:	189-190 °C
Boiling Point:	434.2 °C at 760 mmHg
Flash Point:	216.4 °C
Solubility:	H₂O: 25 mg/mL
Appearance:	off-white solid
Hazard Symbols:	Xn
Risk Codes:	20/21/22
Safety:	36
PSA:	6.48000
LogP:	5.39540

Downstream Products

32943-25-2

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Specification

The Chlorimipramine hydrochloride with the cas number 17321-77-6, is also called (1)3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine monohydrochloride ; (2) 3-Chloroimipramine hydrochloride ; (3) 5H-Dibenz(b,f)azepine-5-propanamine, 3-chloro-10,11-dihydro-; (4)N,N-dimethyl-, monohydrochloride ; (5) Anafranil ; (6) Anaphranil ; (7) Chlorimipramine hydrochloride ; (8) Chloroimipramine monohydrochloride ; (9) Clomicalm ; (10) Clomipramine HCl ; (11) Clomipramine hydrochloride ; (12) EINECS 241-344-3 ; (13) G 34586 ; (14) Hydiphen ; (15) UNII-2LXW0L6GWJ. It belongs to the following product categories such as (1)Organics; (2)Chemical Amines; (3)Amines; (4)Heterocycles; (5)Intermediates & Fine Chemicals; (6)Pharmaceuticals; (7)Serotonin receptor.

Properties of Venlafaxine are: (1)ACD/BCF (pH 5.5): 6.79 ; (2)ACD/BCF (pH 7.4): 76.21 ; (3)ACD/KOC (pH 5.5): 18.76 ; (4)ACD/KOC (pH 7.4): 210.7 ; (5)#H bond acceptors: 2 ; (6)#H bond donors: 0 ; (7)#Freely Rotating Bonds: 4 ; (8)Polar Surface Area: 6.48Å² ; (9)Flash Point: 216.4 °C ; (10)Enthalpy of Vaporization: 69.03 kJ/mol ; (11)Boiling Point: 434.2 °C at 760 mmHg ; (12)Vapour Pressure: 9.63E-08 mmHg at 25°C

The Chlorimipramine hydrochloride appears to be off-White solid. It is used for serotonin reuptake inhibitor. antidepressant and antiobsessional agent. Chlorimipramine hydrochloride is quite harmful by inhalation, in contact with skin and if swallowed. Hence, in case of such dangerous thing, please wear suitable protective clothing.

You can still convert the following datas into molecular structure :
1. SMILES: Cl.Clc1ccc3c(c1)N(c2ccccc2CC3)CCCN(C)C
2. InChI: InChI=1/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

The Chlorimipramine hydrochloride toxic data can be showed in the following sheet.

	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	32mg/kg (32mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970.
dog	LD50	oral	383mg/kg (383mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970.
dog	LD50	subcutaneous	> 400mg/kg (400mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970.
mouse	LD50	intraperitoneal	90mg/kg (90mg/kg)		Drugs in Japan Vol. 6, Pg. 243, 1982.
mouse	LD50	intravenous	22mg/kg (22mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	European Journal of Pharmacology. Vol. 32, Pg. 108, 1975.
mouse	LD50	oral	470mg/kg (470mg/kg)		Drugs in Japan Vol. 6, Pg. 243, 1982.
mouse	LD50	subcutaneous	400mg/kg (400mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970.
rabbit	LD50	intravenous	12mg/kg (12mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970.
rabbit	LD50	oral	792mg/kg (792mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970.
rabbit	LD50	subcutaneous	217mg/kg (217mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2105, 1970.
rat	LD50	intraperitoneal	135mg/kg (135mg/kg)		Drugs in Japan Vol. 6, Pg. 243, 1982.
rat	LD50	intravenous	26mg/kg (26mg/kg)		Drugs in Japan Vol. 6, Pg. 243, 1982.
rat	LD50	oral	914mg/kg (914mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS	European Journal of Pharmacology. Vol. 32, Pg. 108, 1975.
rat	LD50	subcutaneous	1750mg/kg (1750mg/kg)		Drugs in Japan Vol. 6, Pg. 243, 1982.
women	LDLo	oral	51mg/kg (51mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Journal of Analytical Toxicology. Vol. 22, Pg. 612, 1998.
women	TDLo	oral	9mg/kg/9D-I (9mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	American Journal of Psychiatry. Vol. 150, Pg. 165, 1993.
women	TDLo	oral	170mg/kg (170mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 447, 2000.
women	TDLo	oral	360mg/kg/13W- (360mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Journal of Clinical Psychiatry. Vol. 46, Pg. 290, 1985.