Detail of "17369-59-4"

Reference

Comparison of some alkylidenephthalides for antispasmodic effects

Comparison of some alkylidenephthalides for antispasmodic effects. Ko, Wun Chang; Lin, Lung Ching; Lin, Shu Hwa; Hwang, Pi Yeh; Hsu, Chao Yu; Wang, Gwo Yang; Chang, Ching Wu (Dep. Pharmacol., Taipei Med. Coll., Taipei, Taiwan). T'ai-wan Yao Hsueh Tsa Chih, 35(2), 155-61 (English) 1983. CODEN: JTPHAO. ISSN: 0368-4520. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The antispasmodic activity of a new series of synthetic alkylidenephthalides (I; R = Me, Et, Pr, or Bu) on the contraction-relaxation sequence in the guinea pig ileum was studied. The alkylidenephthalides inhibited contractile responses of the ileum to specific agonists, acetylcholine (ACh) and histamine (Hist), and to nonspecific spasmogens, KCl, and BaCl2 in a noncompetitive manner. There was no significant difference found among propylidene- [17369-59-4], butylidene- [551-08-6], and pentylidenephthalide [90965-68-7] on the basis of comparing the pD2' values, but in comparison to ethylidenephthalide [61658-90-0], the pD2' values were much greater. These results suggest that the antispasmodic activities of the alkylidenephthalides may lie in their lipophilic properties, because all the alkylidenephthalides, except ethylidenephthalide, are oily substances. However, each of these 4 I derivs. did not selectively inhibit ACh (0.01 mM)-, Hist (0.01 mM)-, KCl (40 mM)-, and BaCl2 (40 mM)-induced phasic nor tonic contractions. Apparently the mode of action of these compds. may be similar, but different from that of La+3 or papaverine.