Reference

Studies on the metabolism of 5-hydroxytryptamine (serotonin)

Studies on the metabolism of 5-hydroxytryptamine (serotonin). VII. Effects of haloindoles on cerebral 5-HT in various species.In this study， 1075-35-0 and 50-67-9 are also used. Sherman, Arnold D.; Gal, E. Martin (Dep. Psychiatry, Univ. Iowa, Iowa City, Iowa, USA). Psychopharmacol. Commun., 2(3), 285-93 (English) 1976. CODEN: PSCOD8. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Section cross-reference(s): 2 In a comparative study, the effect of intraventricularly or i.p. injected p-chloroamphetamine (I) [64-12-0] and some chloroindoles on cerebral levels of serotonin [50-67-9] was evaluated. 5-Chloroindole [17422-32-1] depressed serotonin levels in the brainstem and telencephalon for 3 days, 6-chloro-2-methylindole [6127-17-9] only during the 1st day. 5-Chloroindazole [698-26-0] had no effect at all. I was more toxic to guinea pigs than to rats. I and 5-chloro-2-methylindole [1075-35-0] had no effect on cerebral sertonin in chicks. Apparently, none of these compds. represented or was converted to a metabolite possibly responsible for the neurotoxic effects of I. .

Synthesis of indoles from N-aryl-1-alkenylsulfinamides

Synthesis of indoles from N-aryl-1-alkenylsulfinamides. Baudin, Jean Bernard; Julia, Sylvestre A. (Lab. Chim., Ec. Norm. Super., Paris 75231, Fr.).Several substances with their cas registry numbers 17422-32-1 and 3189-13-7 may be metioned in this study. Tetrahedron Lett., 27(7), 837-40 (English) 1986. CODEN: TELEAY. ISSN: 0040-4039. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) RC6H4NHSOCR1:CHR2 (R = H, 2-, 3-, 4-MeO, 2-, 4-Cl, 4-Br, 4-Me, R1 = R2 = H; R = R1 = H, R2 = Bu; R = 4-Me, R1 = Me, R2 = H), prepd. from RC6H4N:S:O and R2CH:CR1MgBr, were heated at 100° in toluene to give the indoles I in 19-75% yield. .