Detail of "17452-27-6"

CAS Number:
17452-27-6
Name:
Pyridine,3-isothiocyanato-
Molecular Structure:
Formula:
C₆H₄N₂S
Molecular Weight:
136.17
Synonyms:
Isothiocyanicacid, 3-pyridyl ester (6CI,8CI);3-Isothiocyanatopyridine;Pyridine, 3-isothiocyanato-;Pyridin-3-yl isothiocyanate;3-isothiocyanatopyridine;3-Isothiocyanatopyridin;
Density:
1.14 g/cm³
Boiling Point:
253.8 °C at 760 mmHg
Flash Point:
107.3 °C
Hazard Symbols:
C; Xi
Risk Codes:
34
Safety:
26-36/37/39-45 Details

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Preparation of thiourea derivatives containing piperidine groups as antimicrobial and antiulcer agents: Preparation of thiourea derivatives containing piperidine groups as antimicrobial and antiulcer agents.Some chemicals with cas registry numbers like 556-61-6 and 17452-27-6 are also used. Hasegawa, Hirokazu; Endo, Isamu; Koyama, Shingo; Isozaki, Masashi; Yoshiyama, Yukari; Nozawa, Shigenori; Arakawa, Norio (Terumo Corp., Japan). Eur. Pat. Appl. EP 470006 A1 5 Feb 1992, 17 pp. DESIGNATED STATES: R: BE, CH, DE, FR, GB, IT, LI, NL, SE. (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07C335-08. ICS: A61K031-17. APPLICATION: EP 91-402182 2 Aug 1991. PRIORITY: JP 90-204999 3 Aug 1990; JP 91-193631 9 Jul 1991. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 Title compds. [I; R1, R2 = alkyl; R1R2 = (CH2)4, (CH2)5; R3 = alkyl, cycloalkyl, (CH2)mR4; R4 = (substituted) Ph, naphthyl, pyridyl, furyl, thienyl; m = 0-2; n = 1-5], were prepd. N-[3-[3-(Piperidinomethyl)phenoxy]propyl]-4-(phthaloylamino)butyramid e was refluxed with hydrazine hydrate in EtOH and the residue in EtOH was stirred with MeNCS to give title compd. II. II inhibited peptic ulcer formation in rats due to stress and EtOH by 92.1 and 51.4%, resp., and showed antimicrobial activity against Helicobacter pylori with min. inhibitory concn. 6.25 mg/mL. .