Reference

Experimental evaluation of new Czechoslovak antitussive drug dropropizine (Ditustat)

Experimental evaluation of new Czechoslovak antitussive drug dropropizine (Ditustat). Nosalova, Gabriela; Korpas, Juraj; Strapkova, Anna (Lek. Fak., Univ. Komenskeho, Martin, Czech.). Farmakoter. Zpr., 29(4), 303-17 (Slovak) 1983. CODEN: FAZPAN. ISSN: 0428-0288. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In cats with exptl. cough induced by mech. or chem. irritation of airways, Ditustat (dropropizine)(I) [17692-31-8] (50 mg/kg, i.p., or 150 mg/kg, i.v.) was superior in its antitussive action to prenoxdiazine. It is expected that at therapeutic doses in humans I will not affect respiration or cardiac function.

Pre-screening of carcinogens by studying of DNA synthesis inhibition and gene mutations in mammalian cells

Pre-screening of carcinogens by studying of DNA synthesis inhibition and gene mutations in mammalian cells. Slamenova, D.; Budayova, E.; Gabelova, A.; Dusinska, M. 583-39-1 and 17692-31-8 are also occured in this study. (Cancer Res. Inst., Slovak Acad. Sci., Bratislava 812 32, Czech.). Neoplasma, 33(6), 699-706 (English) 1986. CODEN: NEOLA4. ISSN: 0028-2685. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 1, 8 The ability to induce gene mutations at the HGPRT (hypoxanthine-guanine phosphoribosyl transferase) locus in Chinese hamster V-79 cells and to inhibit DNA synthesis in human EUE cells was investigated for 18 chem. substances and UV light. The aim was to det. whether the inhibition of DNA synthesis in impaired human cells may serve as an indicator of the mutagenicity of the chem. The DNA inhibition test provides preliminary information on the genotoxicity of the chem. substance, although the degree of inhibition of DNA synthesis need not necessarily denote the measure of the mutagenic effect of the substance. Some false pos. results were obsd. It is important to combine this test with mammalian cell in vitro tests. .