Reference

Polymeric reagents for the isolation and protection of carbonyl compounds

Polymeric reagents for the isolation and protection of carbonyl compounds. Lieberman, Seymour; Prasad, Veeramac V. K.; Warne, Patricia A. (Columbia University, USA). U.S. US 4461876 A 24 Jul 1984, 10 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: C08F008-32; C08F008-18. NCL: 525374000. APPLICATION: US 82-416103 9 Sep 1982. DOCUMENT TYPE: Patent CA Section: 35 (Chemistry of Synthetic High Polymers) Section cross-reference(s): 32 Polymers contg. -ONH2 groups are prepd. that are useful for isolating and protecting CO groups, with latter release of the bound CO groups by hydrolysis under mild conditions. Thus, K N-hydroxyphthalimide (prepd. from 13 g K2CO3 and 15.5 g N-hydroxyphthalimide) was treated with 20 g chloromethylated polystyrene, heated 24 h at 80°, and washed. The resin (5 g) was suspended in 200 mL EtOH and 5 mL H2NNH2 and reflux 4 h to give a resin (I) having 1.5 mmol -ONH2 group/g resin. Pregnenolone acetate [1778-02-5], D-glucose [50-99-7], pregnenolone [145-13-1], progesterone [57-83-0], testosterone [58-22-0], dehydroepiandrosterone [53-43-0], and androstenedione [63-05-8] were rapidly bound by I in the presence of AcOH to give 100% oxime formation, and hydrolysis with HCl gave 85-100% regeneration.

Topical compositions for decreasing wrinkles and smoothing skin

Topical compositions for decreasing wrinkles and smoothing skin. Lubowe, Irwin I. (USA ). U.S. US 4474763 A 2 Oct 1984,4 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K037-02; A61K031-56. NCL: 424177000. APPLICATION: US 82-395990 7 Jul 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 62 A topical compn. for smoothing the skin, decreasing wrinkles and improving the moisture level and tone of the skin contains a mixt. of pregnenolone [145-13-1] or its org. salts and elastin in a hydrophilic carrier vehicle. The compn. may include substances from Aloe vera, tocopherols, vegetable, animal and synthetic oils and waxes, allantoin and skin penetration enhancers, such as lower alkyl sulfoxides. Thus, a compn. was prepd. contg. pregnenolone acetate [1778-02-5] 0.025, elastin 1.00, methylparaben 0.025, propylparaben 0.015, Na lauryl sulfate 1.0, propylene glycol 12.0, stearyl alc. 25.0, white petrolatum 25.0, Polyoxyl 40 stearate 5.0, and iso-Pr myristate 0.025% and purified water balance.