Detail of "1779-81-3"

Reference

Antitumor studies of 2-amino-2-thiazoline and other tumor-modifying agents

Antitumor studies of 2-amino-2-thiazoline and other tumor-modifying agents. Pine, Martin J.; Mirand, Edwin A.; Ambrus, Julian L.In this study， 53-86-1 and 147-84-2 are also used.; Bock, Fred G. (Dep. Exp. Ther., Roswell Park Mem. Inst., Buffalo, NY, USA). J. Med. (Westbury, N. Y.), 14(5-6), 433-49 (English) 1983. CODEN: JNMDBO. ISSN: 0025-7850. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) 2-Amino-2-thiazoline (AT) [1779-81-3] and thioproline (TC) [444-27-9], which have been previously proposed as agents of reverse transformation, were examd. as antitumor agents in several rodent tumor systems. AT administration reduced tumor incidence in sym-dimethylhydrazine treated outbred ICR Swiss female mice and doubled the survival of DBA/2Ha female mice infected with polycythemic Friend leukemia virus. Indomethacin [53-86-1], pentoxyphylline [6493-05-6], RA 233 [13665-88-8] and diethyldithiocarbamate [147-84-2], with potential for altering host or tumor prostaglandin levels, platelet aggregation and host immunity, resp., ranged from marginally effective to ineffective against Friend virus infection. AT was, however, ineffective against 4 other induced and transplanted mouse tumors and did not notably increase differentiation or decrease transformation in any of several tumor cell systems. No in vitro or in vivo tumor system was found to be more than marginally affected by TC. Thus, AT alone was of significant antitumor activity in inhibiting late stages of viral- or carcinogen induced tumor progression, but could not be demonstrated as an agent of reverse transformation. .

Antiinflammatory activity of 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles

Antiinflammatory activity of 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles. Isomeric 4-pyridyl and 4-substituted-phenyl derivatives. Lantos, I.; Bender, P. E.; Razgaitis, K. A.; Sutton, B. M.; DiMartino, M. J.; Griswold, D. E.; Walz, D. T. (Res. Dev. Div., Smith Kline and French Lab., Philadelphia, PA 19101, USA). J. 87532-38-5 and 143-33-9 are cas registry numbers of chemicals which are used as reagents here. Med. Chem., 27(1), 72-5 (English) 1984. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 28 The title compds. I (R1 and R2 = Ph, 4-substituted Ph, and pyridyl) prepd. by condensation of appropriately substituted a-bromoketones with 2-aminothiazoline [1779-81-3] and from 1-(benzoyloxy)-1-(4-pyridyl)acetonitrile [72873-67-7] by stepwise reactions were evaluated for antiinflammatory activity using an adjuvant arthritic rat assay system. Immunoregulatory activity was evaluated using low-grade contact sensitivity to oxazolone in C52B1/6 mice. 6-Aryl-5-(4-pyridyl)imidazo[2,1-b]thiazoles showed higher antiinflammatory and immunoregulatory activities than the 5-aryl isomers. A drug-receptor complex is proposed that requires at least 3 sites of interactions. .