Detail of "17795-21-0"

Reference

Preparation of allopurinol injections for intravenous administration

Preparation of allopurinol injections for intravenous administration. Matzko Hollenbach, Katharina; Traser, Ferenc, Mrs.; Mezey, Geza (Szegedi Orvostud. Egy. Gyogyszertara, Szeged, Hung.). Acta Pharm. Hung., 54(4), 187-92 (German) 1984. CODEN: APHGAO. ISSN: 0001-6659. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Injections for i.v. use were prepd. by freeze-drying of allopurinol Na salt (I) [17795-21-0]. I was dissolved in stoichiometric quantities in distd. water and the soln. filtered and filled in suitable lyophilization containers. I stability was dependent on the pH value. I was most stable in solns. with pH 10.3. Only 93% I was found after sterilization at pH 9.6. The solns. were also stored at 5, 25, and 60° for 1 mo in a buffer system. contg. K+, Ca+, Na+, Cl-, KClO3, Ca(ClO3)2, Na citrate, etc. No decompn. products were found in these solns.

Clinical effect of allopurinol on preserved kidneys: A randomized double-blind study

Clinical effect of allopurinol on preserved kidneys: A randomized double-blind study. Toledo-Pereyra, Luis H.Some chemicals with cas registry numbers like 17795-21-0 are also used.; Simmons, Richard L.; Olson, Leslie C.; Najarian, John S. (Dep. Surg., Univ. Minnesota, Minneapolis, Minn., USA). Ann. Surg., 185(1), 128-31 (English) 1977. CODEN: ANSUA5. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Thirty-four paired kidneys from brain-dead cadavers were preserved by hypothermic pulsatile perfusion with silica gel fraction in sep. cassettes. Na allopurinol (I Na salt) [17795-21-0] was added to 1 perfusate and omitted from the other. There was no difference in the short-term or long-term function of either group of kidneys. I does not appear to have as consistent a beneficial effect on nonischemically damaged human kidneys as that obsd. exptl. on ischemically damaged canine organs. .