Detail of "1780-26-3"

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Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56Lck inhibitors: Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56Lck inhibitors.Several substances are used for example 1780-26-3 and 302961-78-0 which are their cas registry numbers. Chen, Ping; Norris, Derek; Das, Jagabandhu; Spergel, Steven H.; Wityak, John; Leith, Leslie; Zhao, Rulin; Chen, Bang-Chi; Pitt, Sidney; Pang, Suhong; Shen, Ding Ren; Zhang, Rosemary; De Fex, Henry F.; Doweyko, Arthur M.; McIntyre, Kim W.; Shuster, David J.; Behnia, Kamelia; Schieven, Gary L.; Barrish, Joel C. (Department of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA). Bioorganic & Medicinal Chemistry Letters, 14(24), 6061-6066 (English) 2004 Elsevier B.V. CODEN: BMCLE8. ISSN: 0960-894X. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 7 A series of substituted 2-(aminoheteroaryl)-thiazole-5-carboxamide analogs have been synthesized as novel, potent inhibitors of the Src-family kinase p56Lck. Among them, compd. I displayed superior in vitro potency and excellent in vivo efficacy. .