Detail of "17833-53-3"

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CAS Number:
17833-53-3
Name:
Aspartic acid,N-methyl-
Superlist Name:
2-Methylaminosuccinic acid
Molecular Structure:
Formula:
C₅H₉NO₄
Molecular Weight:
147.13
Synonyms:
Asparticacid, N-methyl-, DL- (8CI);DL-Aspartic acid, N-methyl-;DL-N-Methylasparticacid;N-Methyl-DL-aspartate;N-Methyl-DL-aspartic acid;
Density:
1.343 g/cm³
Boiling Point:
258.2 °C at 760 mmHg
Flash Point:
110 °C
Solubility:
H2 O: 25 mg/mL, clear, colorless
Safety:
22-24/25 Details

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Assay:≥98% Appearance:White Crysta...

Product Name：N-Methyl-DL-aspartic acid MF：C5H9NO4 MW：147.13

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N-methyl-DL-aspartic acid

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Kainic acid and the glutamate receptor: Kainic acid and the glutamate receptor. Hall, J. G.; Hicks, T. P.; McLennan, H. (Dep. Physiol., Univ. British Columbia, Vancouver, B. C., Can.). Neurosci. Lett., 8(2), 171-5 (English) 1978. CODEN: NELED5. ISSN: 0304-3940. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) On 22 of 25 ventrobasal thalamus neurons of anesthetized rats, the excitatory action of 0.4 M L-glutamic acid (I) [56-86-0] was reduced or abolished by the antagonists 0.5 M glutamic acid di-Et ester (II) [16450-41-2] (12 neurons) and 0.2 M D-a-aminoadipic acid (III) [7620-28-2] (10 neurons) related to the excitatory action of 50 mm kainic acid (IV) [487-79-6] which was usually unaffected or only minimally decreased. When compared to the excitotoxic agent 0.1 M N-methyl-DL-aspartic acid (V) [17833-53-3], I action was reduced by II relative to that of V, and in the presence of III, I was less affected than V. Apparently, I and IV elevate neuronal firing rate by different mechanisms involving different receptor populations.

A role for taurine in the maintenance of homeostasis in the central nervous system during hyperexcitation?: A role for taurine in the maintenance of homeostasis in the central nervous system during hyperexcitation?. Lehmann, Anders; Hagberg, Henrik; Hamberger, Anders (Inst. Neurobiol., Univ. Goeteborg, Goeteborg, Swed.). Neurosci. Lett., 52(3), 341-6 (English) 1984. CODEN: NELED5. ISSN: 0304-3940. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The aspartate congener N-methyl-D,L-aspartic acid (NMA) [17833-53-3] stimulated the release of endogenous taurine [107-35-7] by rabbit hippocampus in vivo in a Ca2+-dependent manner as detd. by the brain dialysis technique. Furthermore, exogenous taurine (1-10 mM) inhibited the NMR-induced Ca2+ influx into intracellular compartments. Apparenly, the extracellular taurine concn. may control Ca2+ movement and thereby provide a homeostatic mechanism in situations of excessive excitation.