Detail of "17916-88-0"

Reference

Preparation of D-valine from N-acetyl-DL-valine by enzyme catalytic process

All Rights Reserved. Preparation of D-valine from N-acetyl-DL-valine by enzyme catalytic process. Wang, Ping; Liu, Zenghui; Gu, Yuqiang; Wan, Chunlei; Yu, Peihua ( Zhangjiagang Huachang Pharmaceutical Co., Ltd., Peop. Rep. China). Faming Zhuanli Shenqing Gongkai Shuomingshu CN 1900053 A 24 Jan 2007, 8pp. (Chinese). (People's Republic of China). CODEN: CNXXEV. APPLICATION: CN 2010-41056 21 Jul 2006. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) The title method includes: (1) selecting N-acetyl-DL-valine as raw material, dissolving at a N-acetyl-DL-valine/water wt.Some commonly used reagents like 67-56-1 and 17916-88-0 are used in this experiment. ratio of 1 : (10-14) to obtain a soln., adding aminoacylase as catalyst 0.1-0.3 wt.% of the soln., and carrying out enzyme catalytic reaction at 30-40°C for 30-36 h, (2) vacuum-concg. the resoln. reaction soln. under vacuum degree of (-0.085)-(-0.1) MPa, cooling to 30±5°C when crystals ppt., pptg. L-valine crystal by using alc. (methanol or ethanol) as solvent, and recovering mother liq., (3) evapg. the mother liq., cooling at 0-(-10)°C to obtain N-acetyl-D-valine, carrying out hydrolysis reaction by using 3.0-4.0 mol/L hydrochloric acid as solvent while controlling N-acetyl-D-valine concn. of 10-15%, removing hydrochloric acid after the reaction is completed, standing, and cooling to obtain D-valine coarse product crystals, and (4) carrying out recrystn. by dissolving D-valine with water to obtain D-valine concn. of 8-12%, decolorizing with activated carbon, vacuum-concg. to supersatd. state, cooling, and crystg. to obtain D-valine refined product. .